The invention comprises a dermal/epidermal skin equivalent for studying epidermal development, the role of stem cells in human skin as well as the response to exogenous stimuli such as compounds used in cosmetic or pharmaceutical mixtures.
The site-directed modification of e.g. biomolecules is often time consuming and laborious. This invention provides a high yielding and highly specific method to link nearly any molecule to nearly any other molecule. The “Click reaction” used is the well known Diels-Alder reaction with inverse electron demand. In this fast reaction an appropriate, easily functionalized dien (e.g. Tetrazin) is reacted with an appropriate functionalized dienophil (e.g. Olefin) to yield the conjugate. The release of nitrogen makes the reaction irreversible. No side reactions occur. Further the Intellectual Property covers specific information regarding the ligation of a diagnostic marker AND a therapeutic agent AND a biomolecule. Convincing synthetic data are available for the ligation of peptide with peptide, peptide with marker molecule, peptide with therapeutic agent, peptide with oligo nucleotide, dendritic structure and specific surface modification by means of this technology.
High speed imaging in single spot laser scanning imaging is limited by saturation effects of the fluorescence process in the sample as well as by destructive processes due to the high intensity in the focal spot. The only way to overcome that limitation is to use multiple spots at the same time. We developed a Multi-Photon Multi-Spot Scanning Device which is applicable especially in laser scanning devices such as confocal laser scanners and multi-photon microscopes. It can be used to speed up imaging of living cells which would be harmed by a stronger single beam.
DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for positron electron tomography (PET). Compatibility of light detection with PET has been accomplished by developing an optical detector that consists of a 25 mm x 100 mm photon sensor (liquid cooled) for light detection, a microlens array for field-of-view definition, a septum masks for cross-talk suppression, and a transferable filter for wavelength selection.
This invention describes a simple and robust navigation aid for physicians in bronchoscopy or similar interventional surgery (angiography; implanting of vessel stents as well as cardiac pacemaker). The interventional device can be monitored and in real time and at a defined localized spot a biopsy can be taken. It improves accuracy also in the case of movement of the organ structures in opposite to established procedures. A prototype phantom has been tested successfully at the DKFZ together with the software.
Optical fluorescence and gamma-labeled radio-pharmaceutical imaging offer complementary ways of probing and assessing the physiology of small animals. With the increasing use of both methods for functional molecular imaging in small animal models for applications such as cancer research and drug development, it has become more important to integrate their results, particularly for studies of the same animal. This can be performed through image registration of separate studies or through simultaneous tomographic acquisition with implicit registration of the two imaging modalities. DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for single-photon emission computed tomography (SPECT).
New method for producing a highly diverse antibody library, where pro-teins/antibodies can be selected for specific applications. A large and, compared from cell to cell, highly uniform number of antibodies is covalently attached to the surface of a eukaryotic cell. Using this technology, specific antibodies can be selected together with the presenting cell out of a high number of cells in a comparatively easy way. The technology can also be used humanizing a hybridoma cell line by enabling the homologous recombination of the constant do-mains of human immunoglobulins with the respective gene.
The present technology provides 3'-photolabile nucleoside derivatives for producing nucleotides. The resulting oligonucleotides built up on the support by light-controlled synthesis are linked to the solid phase via the 5' end and thus can be used for investigating reactions that require free 3'-OH ends, for example certain DNA-enzyme interactions.
The present invention relates to a process for the photolithographic biochip synthesis in which photolabile protective groups of the 2-(2-nitrophenyl) ethyl type are used, wherein the irradiation step common for the photolithographic chip synthesis is carried out in the presence of base, preferably a non-nucleophilic base.
Wissenschaftler des KIT haben eine Methode und eine Vorrichtung entwickelt, mithilfe derer lange hochfeste Halbzeuge aus Metall mit verhältnismäßig geringem Aufwand hergestellt werden können. Dabei werden durch massive plastische Umformung („High Pressure Torsion“) nicht nur die mechanischen Eigenschaften der Werkstoffe verbessert, sondern auch die physikalischen, wie z. B. die magnetischen Eigenschaften von ferromagnetischen Legierungen, verstärkt. Auch die Verarbeitung vorgepresster Rohlinge aus metallischen Pulvern ist möglich.
OPoLiCom is a system that continuously monitors the access impedance over frequency. If the access impedance spectral density below a threshold value, in the respective frequency range, no power is fed. Since the maximum power consumption of a PLC transmitter is limited, it ensures that in the frequency ranges with sufficiently high access impedance sufficient power can be fed. This is necessary for a good signal-to-noise ratio. By using OFDM with strong channel coding as in the just now standardized method, the absence of a portion of transmission frequencies can be compensated without any information to the receiver. This allows a standard-compliant implementation.
Die neuentwickelte Technologie betrifft eine Vorrichtung zur Temperierung eines Extruders oder eines Plastifizierzylinders, wobei diese mindestens eine temperierende Rohrschlange umfasst, die mäanderförmig gebogen ist, und in mittelbarem oder unmittelbarem Kontakt mit dem Extruder oder dem Plastifi-zierzylinder steht.
Die Erfindung betrifft ein Verfahren zur Abstandsbestimmung mittels eines interferometrischen Sensors. Der Sensor fokussiert Licht auf einen Punkt des Messobjektes. Dieses Licht wird zumindest teilweise in den Sensor zurückreflektiert, hinsichtlich seiner Phasenlage analysiert und in einen Abstandswert umgerechnet. Durch laterales Scannen des Messobjektes relativ zum Sensor lassen sich Mikrostrukturen und Formen mit hoher Genauigkeit erfassen. Da mehrere hunderttausend Abstandsmesswerte pro Sekunde ermittelt werden, können sehr hohe Messgeschwindigkeiten erzielt werden.
The invention describes a method for the in-situ conversion of chemically fixed carbon dioxide into low-molecular weight organic compounds by direct heterogeneous catalytic or electrochemical hydrogenation
Ein neu entwickelter urodynamischer Messkatheter enthält einen triaxialen Beschleunigungssenor und mehrere Drucksensoren. Mithilfe des neuen Urokatheters kann die Diagnose von Inkontinenz bei Patienten und damit deren Behandlung verbessert werden. Ein Prototyp des Urokatheter befindet sich zurzeit in Erprobung.
Lasers as sources for coherent and intense light are used in many high-tech applications and medical devices. Generally, the generation of Laser-light is characterized by a significant level of optical and electrical energy input and low efficiency.
Contrary to the Laser, BEL utilizes an organic dye/polymer system, which is arranged between two mirrors forming an optical micro-cavity. The incoming light is multiply reflected between the mirrors, giving rise to an effective photon mass and a confining potential – key prerequisites for the Bose-Einstein condensation of photons. Thermalisation is achieved by the photon scattering off the dye molecules, resulting in a strong light concentration effect into the centre of the confining potential, where the potential energy is minimized. The spatial concentration is a consequence of the thermalisation of the trapped photon gas.
Commercial Opportunity:
For many Laser applications, coherent but not necessarily monochromatic light is required. The strong light concentration effect of BEL and the generation of coherent light with high intensity offer opportunities for a range of applications. For these applications, BEL can be a efficient light source for coherent visible and UV light. In contrast to a Laser, where significant share of the energy is lost in heat, BEL allows the design of an efficient solid state “cold Laser”.
Rückmeldung
