The invention provides a needle-based navigation system for CT-guided radiofrequency ablation of the liver. The key facts are: (1) Precise intervention and navigation aid for soft tissue surgery; (2) Real-time observation and supervision; (3) Inexpensive hardware/software equipment
Rocaglamide makes tumour cells more susceptible to anti-proliferative agents while leaving normal cells unaffected. This allows dose reduction of apoptosis inducers and in parallel improves dramatically the patient’s condition during cancer treatment.
The current invention provides a prophylactic HPV vaccine. Immunization against peptides from the HPV L2 protein gives a robust immune reaction that provides cross-protection against a variety of other high-risk HPV strains. Tha vaccine is based on a thioredoxin-L2 construct and can be produced in standard E. coli bacteria, which makes a cost-effective production feasible.
To optimize the treatment plan for radiotherapy is time consuming and requires high memory and CPU. We developed the “Local Dose Shaping for Planning Treatment in Radiotherapy” as a method to simplify this process. The physician can use intuitive computer animation (i.e. “”dose lines can be moved by drag an drop””) to address individual local dose requirements.
The invention provides a long time culture model which can be used for the production of skin equivalents with a life span of at least 10 weeks.
Partial deficiency of Rspo3 leads to a significant increase of bone mass. These results indicate a major role for Rspo3 as a bone anabolic marker and/or target. Thus, Rspo3 antagonists are drug candidates for the treatment of osteopenia disorders, particularly in conditions associated with increased bone resorption.
Monoclonal Antibody against Neurofibromin as a diagnostic and prognostic Marker for Glioma Treatment. The proof of concept is established with Biopsy Material. The antibody is fast, reliable & ready to use.
Many light emitting entities routinely used, in cell biological settings show a dipole orientation. If the exact z position of the light emitting entity is unknown, using simple two-dimensional Gaussian fit algorithms to the light intensity distribution of a range of emitted light, may lead to calculation errors of the x- and y-position of several 10nm. The invention discloses a method for calculation of the exact spatial position and orientation of a light emitting in a sample.
Currently, Multileaf Collimators (MLC) are established and state of the art in numerous devices for radiotherapy used for cancer treatment. However, the established MLC comprising 80 and more leafs require an enormous space at the level of the leaves together with corresponding drive elements and position measuring/ acquisi-tion. Since space is very limited within the head of linear accelerators DKFZ developed a smaller sized Compact MLC, which prototype was tested successfully.
The TNF-Related Apoptosis-Inducing Ligand (TRAIL) has been shown to be involved in apoptosis, cell survival, migration and proliferation. DKFZ inventors identified a multitude of genes encoding proteins that are associated with cell death induction by TRAIL. According to its individual function, inhibition or activation of the respective gene or gene product is assumed to have beneficial effects on cancer treatment. The technology can be used to screen for small molecules, antibodies or siRNAs that are capable of modulating TRAIL-induced cell death, thus having the potential to kill cancer cells or to sensitize cancer cells to established cancer drugs.
The technology is a method for determining the in vivo localization of double-strand breaks in a host cell using a linear polynucleotide.
90% of sporadic colorectal carcinomas carry loss-of-function mutations in the adenomatous polyposis coli (APC) gene, which encodes a scaffolding protein mediating constitutive destruction of the ?-catenin transcriptional co-activator in the absence of Wnt ligand. DKFZ inventors detected NKD1 and C10orf54 as biomarkers for identification of Wnt/?-catenin modulating compounds, such as small molecules, interfering RNAs, peptides and antibodies and thus can be used for the development of a kit or an assay for detection of such compounds. This kit or assay can additionally be used as a companion diagnostic resource to identify patients in need of a treatment that modulates the Wnt/?-catenin signaling pathway (e.g. targeted therapy).
The invention proposes to use the travelling wave concept, but to couple high frequency waves only into an object to be investigated. However, in contrast to the prior art, the high frequency device enables to couple in RF waves targeted into a particular section of interest of the object. This offers the advantage that the excluded parts are not unnecessarily exposed to the RF waves and do not contribute to RF expo-sure limit calculations, which allows for a coupling in of a larger dose of the RF energy at a location where it is required. The hardware MRI device has a coaxial arrangement of tubular elements.
The current technology demonstrates that treatment with ciprofloxacin leads to immunosuppression of T-cells isolated from patients with atopic dermatitis.
The Wnt signaling pathway plays an important role in the regulation of cell proliferation and differentiation. Aberrant activation of the Wnt signaling pathway is known to promote uncontrolled cell growth and survival. Compound library screening and med-chem based structure activity improvement revealed potent Wnt signaling inhibitors that selectively affected carcinoma cell lines. In addition, further experiments proved these compounds to induce apoptosis.
Cardiac hypertrophy is characterized by a global increase in transcription and protein per cell. Cyclin-dependent kinase 9 (CDK9) is the main driver for transcription and is necessary for hypertrophy in cardiomyocytes. DKFZ scientists have shown that wogonin is a potent inhibitor of CDK9 with no or very low toxicity to normal tissues. Wogonin can be used for preventing cardiac hypertrophy.
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