Peptides for Diagnosis and Therapy of Celery Allergy and of Hazelnut Allergy

<strong>Background</strong><br>

Celery is a frequent cause of food allergy in pollen-sensitized patients and may induce severe allergic reactions. Allergic reactions against celery are of major clinical relevance due to celery's wide presence in convenience foods and spice. Approximately 3% – 4% of the European and American population and 5% of young children are affected by immunoglobulin E (IgE) mediated food allergy. The symptoms ranging from mild oral pruritus to a possible life-threatening anaphylactic shock.</p> <strong>Technology</strong><br> We offer novel linear IgE-binding peptide epitopes of the major celery aller-gen Api g1 for the diagnosis and therapy of celery allergy. The peptides can also serve as a basis for the detection of traces of Api g1 allergens in food and other products. Based on the novel peptides, a high specific assay was developed which allows the differentiation between celery allergic patients and healthy individuals.</p> <b>Benefits:</b> <ul> <li>Highly specific diagnosis of celery allergic patients (IgE detection)</li> <li>Assay allows a reliable, rapid and easy diagnosis</li> <li>Peptides are usable for chip and other high throughput applications</li> <li>Peptides might be suitable for a specific desensitization of patients (Immunotherapy)</li> <li>Antibodies against these peptides can be used for the detection of traces of celery in food and other products</li> </ul><br> <p><strong>IP Rights</strong><br> EP application (July 2010)<br> PCT application (July 2011) <br> <br> <strong>Origin</strong><br> The invention was made at the Charité – Universitätsmedizin Berlin.</p> <b>Find the technology offer and contact details here: <a href=“http://www.ipal.de/technologieangebote/10048″ target=“_blank“>http://www.ipal.de/technologieangebote/10048</a></b>

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