Polyglycerin – PEG-drug conjugates

<strong>Technology</strong><br>

A novel drug polymer conjugate consisting of a dendritic polyglycerine (PG) core of 3-5 or more glycerol units and a polyethylene glycol shell has been developed. The pharmaceutically or diagnostically compound is covalently bound to a glycerol unit through a cleavable linker (and optionally an addi-tional spacer). Dependently on the used linker, the compound can be cleaved physically or chemically e.g. by light, heat, or by hydrolysis, pH-dependent cleavage or cleavage by enzymes. As there are multiple glycerol units, more than one binding site exists, so that more than one active compound can be coupled to the same carrier molecule. Moreover, one carrier molecule also enables the loading of different pharmaceutically compounds (combinational therapy). These carriers are suitable for conjugation of various drug agents or diagnostically compounds such as e.g. cytostatic agents, cytokines, immune-suppressants, virostatics and radioactive agents, light-emitting or light absorbing substance, which allows the application in therapies of various diseases. The polymer drug conjugate may be suitable for the patient in an injectable form, as a tablet or a capsule, or as composition for inhalation. </p> <p><strong>Benefits</strong> <ul> <li>Carrier allows high loading with active compounds due to multiple binding sites and divers functionalizing with various reactive groups </li> <li>Design of prodrugs comprising advantageous combination of different pharmaceutically active compounds-> individualized modes of treatment</li> <li>Easy drug conjugate preparation in three steps with high yield </li> <li>Very high biocompatibility of branched polyglycerol </li> <li>Controlled loading and release of the drugs by in vivo stimuli at the site of action (e.g. by pH changes or enzyme)</li> <li>Tumor growth inhibition in the ovarian carcinoma A2780 xenograft model by the application of Doxorubicin</li> </ul> <p><strong>IP Rights</strong><br> European Patent Applic. (02/2009)<br> US Application (03/2009) <br> <br> <strong>Origin</strong><br> The invention was made at the Freie Universität Berlin and the KTB Tumorforschungsgesellschaft mbH Freiburg.</p>

Weitere Informationen: PDF

ipal GmbH
Tel.: +49 (0)30/2125-4820

Ansprechpartner
Dr. Dirk Dantz

Media Contact

info@technologieallianz.de TechnologieAllianz e.V.

Alle Nachrichten aus der Kategorie: Technologieangebote

Zurück zur Startseite

Kommentare (0)

Schreiben Sie einen Kommentar

Neueste Beiträge

Analyse von Partikeln des Asteroiden Ryugu liefert überraschende Ergebnisse

Eine kleine Landekapsel brachte im Dezember 2020 Bodenpartikel vom Asteroiden Ryugu zur Erde – Material aus den Anfängen unseres Sonnensystems. Gesammelt hatte die Proben die japanische Raumsonde Hayabusa 2. Geowissenschaftler…

Kollision in elf Millionen Kilometern Entfernung

Die im letzten Jahr gestartete NASA-Raumsonde DART wird am 27. September 2022 um 1.14 Uhr MESZ in elf Millionen Kilometer Entfernung von der Erde erproben, ob der Kurs eines Asteroiden…

Wie die Erderwärmung astronomische Beobachtungen beeinträchtigt

Astronomische Beobachtungen mit bodengebundenen Teleskopen sind extrem abhängig von lokalen atmosphärischen Bedingungen. Der menschgemachte Klimawandel wird einige dieser Bedingungen an Beobachtungsstandorten rund um den Globus negativ beeinflussen, wie ein Forschungsteam…

Partner & Förderer