Gold Nanoparticles Functionalized with Dendritic Polyglycerol Sulfates

<strong>Background</strong><br>

As selectins mediate the first contacts of leukocytes to the endothelium, the initial events of all kind of inflammatory responses, selectins are ideal targets for the therapeutic intervention of inflammatory diseases. <br><br> Dendritic polyglycerol sulfates (dPGS) alone and with aminoalcohols functionalized gold nanoparticles each have been shown to be good selectin inhibitors, as they prevent L- and P-selectins to bind their natural ligands with IC50 values in the nanomolar and picomolar range. <br><br> <strong>Technology</strong><br> We offer synthesized gold nanoparticles functionalized with highly branched polyglycerol sulfates, showing a high affinity for L- and P-selectins with IC50 values in the femtomolar range and therefore having a better anti-inflammatory potential compared to dPGS and aminoalcohol-functionalized nanoparticles alone. <br><br> Besides their use in the therapy of inflammatory diseases, dPGS-functionalized nanoparticles can also be used for diagnostic purposes. By using dPGS functionalized nanoparticles, selectin expressing inflammatory tissues can be localized and visualized. <br><br> <strong>Benefits</strong> <ul> <li>Improved selectin inhibition with IC50 = 180 fM </li> <li>Branched polyglycerols show high biocompatibility</li> <li>Visualization of gold nanoparticles by MRT possible </li> </ul> <p><strong>IP Rights</strong><br> DE patent application filed 05/2011<br> PCT application filed 05/2012 <br><br> <strong>Patent Owner</strong><br> Charité Universitätsmedizin Berlin<br> Freie Universität Berlin</p>

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