Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Drug against breast cancer is also highly potent against a frequent form of leukaemia

17.05.2016

Acute myeloid leukaemia (AML) is the most frequent form of blood cancer. In about 30 percent of all AML patients, a mutation in the FLT3 tyrosine kinase accelerates the course of the disease. Common therapies were not successful in healing these patients so far. Researchers at the University of Veterinary Medicine, Vienna managed now to specifically target and kill AML cancer cells carrying this activating mutation. They used an agent that had recently been approved for breast cancer therapy. The study was published in the top hemato-oncology journal Blood.

Cancer cells have an abnormal cell division and survival machinery - they grow faster than they die. For their permanent development, they produce an excess of growth factors and nutrients and block the body’s own safety mechanisms. To do so, cancer cells harbour mutations, which enable a continuous cellular growth.


Before treatment

Photo: Iris Uras/Vetmeduni Vienna


After treatment: The breast cancer treatment downregulates FLT3. The cancer cells die.

Photo: Iris Uras/Vetmeduni Vienna

In acute myeloid leukemia (AML), an activating mutation in the FLT3 tyrosine kinase is the most frequent mutation found in patients. According to first author Iris Uras from the Institute of Pharmacology and Toxicology at the Vetmeduni Vienna, these cancer cells depend on FLT3 – is FLT3 blocked, cancer cells die.

Common FLT3 inhibitors do not suffice to survive

Activation of signalling pathways caused by mutations in tyrosine kinases is involved in the pathogenesis of AML. Targeted pharmacological inhibition of such mutant genes holds great therapeutic potential in AML.

Because of the clinical importance of FLT3-mutations in disease progression in AML, there have been considerable efforts to develop FLT3 inhibitors which block the kinase activity and subsequently shall impair cell growth. Yet the initial great hopes have not been fulfilled and the clinical impact of FLT3 kinase inhibitors is limited. Responses in patients with FLT3 mutations have been transient and resistant clones have emerged rapidly.

Breast cancer therapeutic blocks the production of the FLT3 gene

In her study, Uras uncovered a novel therapeutic approach to treat patients with AML with FLT3 mutations. She found that another tumor-promoting factor, the enzyme CDK6, directly regulates and initiates the production of FLT3 and thus cause the disease.

The active agent developed for breast cancer treatment blocks the activity of CDK6 and subsequently downregulates FLT3. “We found a novel therapeutic window that attacks the dependency of a cancer cell on its growth regulator “, said Uras. The compound from breast cancer therapy deprives the cancer cells of “nutrients”. AML cancer cells carrying the mutation died immediately in the experiments. The drug does not affect cells lacking the mutation proving to be highly specific.

Active agent already approved

The advantage of having this agent at hand is the fact that it has already been approved for the therapy of breast cancer in 2015 – it significantly enhanced the lifespan of patients with breast cancer. Hence, clinical studies can be rapidly initiated without passing a long series of tests in advance.

A combination with compounds that block FLT3 kinase activity increases the efficacy of the breast cancer drug. The driver of the disease and as a consequence the continuous cell growth is suppressed. “We are attacking FLT3 from two sides there – blocking its expression and inhibiting its activity. A combination therapy could be a breakthrough for many patients suffering from leukaemia,” explained Uras.

About acute myeloid leukaemia

Leukaemia, also known as blood cancer, is a hematopoietic malignancy. The most frequent form is AML, acute myeloid leukaemia. Patients with AML have poor prognosis and high mortality rate despite considerable advances in chemotherapy and hematopoietic stem cell transplantations.

Service
The article „Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6“ by Iris Uras, Gina Walter, Ruth Scheicher, Florian Bellutti, Michaela Prchal-Murphy, Anca S. Tigan, Peter Valent, Florian H. Heidel, Stefan Kubicek, Claudia Scholl, Stefan Fröhling and Veronika Sexl was published in Journal Blood.
DOI: ´http://dx.doi.org/10.1182/blood-2015-11-683581
http://www.bloodjournal.org/content/early/2016/04/20/blood-2015-11-683581?sso-ch...

About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna in Austria is one of the leading academic and research institutions in the field of Veterinary Sciences in Europe. About 1,300 employees and 2,300 students work on the campus in the north of Vienna which also houses five university clinics and various research sites. Outside of Vienna the university operates Teaching and Research Farms. http://www.vetmeduni.ac.at

Scientific Contact:
Iris Uras
Institute of Pharmacology and Toxicology
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 699 182 04 603
iris.uras@vetmeduni.ac.at

Released by:
Heike Hochhauser
Corporate Communications
University of Veterinary Medicine Vienna (Vetmeduni Vienna)
T +43 1 25077-1151
heike.hochhauser@vetmeduni.ac.at

Weitere Informationen:

http://www.vetmeduni.ac.at/en/infoservice/presseinformation/presseinformationen-...

Heike Hochhauser | Veterinärmedizinische Universität Wien

Weitere Nachrichten aus der Kategorie Biowissenschaften Chemie:

nachricht Neues Schiff für die Fischerei- und Meeresforschung
22.03.2017 | Johann Heinrich von Thünen-Institut, Bundesforschungsinstitut für Ländliche Räume, Wald und Fischerei

nachricht Mit voller Kraft auf Erregerjagd
22.03.2017 | Helmholtz-Zentrum für Infektionsforschung

Alle Nachrichten aus der Kategorie: Biowissenschaften Chemie >>>

Die aktuellsten Pressemeldungen zum Suchbegriff Innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Gigantische Magnetfelder im Universum

Astronomen aus Bonn und Tautenburg in Thüringen beobachteten mit dem 100-m-Radioteleskop Effelsberg Galaxienhaufen, das sind Ansammlungen von Sternsystemen, heißem Gas und geladenen Teilchen. An den Rändern dieser Galaxienhaufen fanden sie außergewöhnlich geordnete Magnetfelder, die sich über viele Millionen Lichtjahre erstrecken. Sie stellen die größten bekannten Magnetfelder im Universum dar.

Die Ergebnisse werden am 22. März in der Fachzeitschrift „Astronomy & Astrophysics“ veröffentlicht.

Galaxienhaufen sind die größten gravitativ gebundenen Strukturen im Universum, mit einer Ausdehnung von etwa zehn Millionen Lichtjahren. Im Vergleich dazu ist...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Auf der Spur des linearen Ubiquitins

Eine neue Methode ermöglicht es, den Geheimcode linearer Ubiquitin-Ketten zu entschlüsseln. Forscher der Goethe-Universität berichten darüber in der aktuellen Ausgabe von "nature methods", zusammen mit Partnern der Universität Tübingen, der Queen Mary University und des Francis Crick Institute in London.

Ubiquitin ist ein kleines Molekül, das im Körper an andere Proteine angehängt wird und so deren Funktion kontrollieren und verändern kann. Die Anheftung...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Physiker erzeugen gezielt Elektronenwirbel

Einem Team um den Oldenburger Experimentalphysiker Prof. Dr. Matthias Wollenhaupt ist es mithilfe ultrakurzer Laserpulse gelungen, gezielt Elektronenwirbel zu erzeugen und diese dreidimensional abzubilden. Damit haben sie einen komplexen physikalischen Vorgang steuern können: die sogenannte Photoionisation oder Ladungstrennung. Diese gilt als entscheidender Schritt bei der Umwandlung von Licht in elektrischen Strom, beispielsweise in Solarzellen. Die Ergebnisse ihrer experimentellen Arbeit haben die Grundlagenforscher kürzlich in der renommierten Fachzeitschrift „Physical Review Letters“ veröffentlicht.

Das Umwandeln von Licht in elektrischen Strom ist ein ultraschneller Vorgang, dessen Details erstmals Albert Einstein in seinen Studien zum photoelektrischen...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Die „Panama Papers“ aus Programmierersicht

22.03.2017 | Veranstaltungen

Über Raum, Zeit und Materie

22.03.2017 | Veranstaltungen

Unter der Haut

22.03.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Die „Panama Papers“ aus Programmierersicht

22.03.2017 | Veranstaltungsnachrichten

Neues Schiff für die Fischerei- und Meeresforschung

22.03.2017 | Biowissenschaften Chemie

Mit voller Kraft auf Erregerjagd

22.03.2017 | Biowissenschaften Chemie