C5aR

Antibody therapy reduces asthma in mice

Asthma rates are rapidly increasing, particularly in children. Although asthma is mediated in part by activation of special immune cells called Th2 cells, the precise causes are unclear. Now, in a study appearing in the March issue of the Journal of Clinical Investigation, Jörg Köhl and colleagues from the Cincinnati Children’s Hospital Research Foundation report that a small allergy-inducing protein called C5a produced in the lungs can prevent or induce asthma, depending upon the timing of a