Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Treat snoring to avoid deadly heart failure

05.12.2012
Patients with obstructive sleep apnea have the same early CVD damage as diabetics

Patients with obstructive sleep apnea have the same early cardiovascular damage as diabetics, according to research presented at EUROECHO and other Imaging Modalities 2012. The study1 was presented by Dr Raluca Mincu from Bucharest, Romania.

EUROECHO and other Imaging Modalities 2012 is the annual meeting of the European Association of Cardiovascular Imaging (EACVI)2, a registered branch of the European Society of Cardiology (ESC)3. It takes place 5-8 December in Athens, Greece, at the Megaron Athens International Conference Centre.

Obstructive sleep apnea (OSA) is a common sleep disorder that has been associated with cardiovascular disease. OSA increases the risk of hypertension, arrhythmias, myocardial infarction, stroke, sudden cardiac death and heart failure.

Dr Mincu said: "There are not enough studies in the medical literature on early cardiovascular dysfunction in patients with OSA, when active steps can be taken to prevent progression to heart failure."

She added: "Because OSA leads to so many cardiovascular disorders, we compared early cardiovascular dysfunction in OSA patients and patients with diabetes mellitus, which is a typical risk factor for cardiovascular disease."

The study assessed endothelial and arterial function in 20 patients with moderate to severe OSA (and no diabetes), 20 patients with treated type 2 diabetes mellitus (matched for age, sex and cardiovascular risk factors), and 20 healthy controls (age and sex matched).

In all subjects, arterial function was assessed by intima-media thickness (IMT). Arterial stiffness was measured by young elastic modulus, beta stiffness index, arterial compliance, first systolic peak and second systolic peak. Endothelial function was assessed by flow mediated dilatation (FMD).

Dr Mincu said: "Patients with moderate to severe OSA had endothelial dysfunction and higher arterial stiffness than controls, and their results were similar to patients with diabetes mellitus. This suggests that OSA is associated with a high risk for cardiovascular disease."

She added: "Patients in the OSA and diabetes groups had a higher intima-media thickness, which shows that their arteries are remodelled in a pathological way."

All five parameters of arterial stiffness were significantly higher in the OSA and diabetes mellitus groups compared to controls. FMD was lower in these groups, meaning they had poorer endothelial function than controls.

Dr Mincu said: "Patients should realise that behind snoring there can be a serious cardiac pathology and they should get referred to a sleep specialist. If they are diagnosed with obstructive sleep apnea, they are at increased risk of cardiovascular disease and need to adopt a heart healthy lifestyle to reduce that risk."

She added: "Although OSA treatment with continuous positive airway pressure (CPAP) is inconvenient – it requires sleeping with a mask – patients should use it because it can reverse the parameters measured in our study."

Dr Mincu concluded: "Our study is a signal for cardiologists, pneumologists and general practitioners to work together to actively diagnose obstructive sleep apnea, administer the appropriate treatment (CPAP) and assess arterial function. This will help avoid progression of early cardiovascular dysfunction through to heart failure, the final stage of heart disease."

Notes to editor

1 Obstructive sleep apnea determines endothelial dysfunction and increased arterial stiffness, similarly with diabetes mellitus (abstract 50318)

2 About the European Association of Cardiovascular Imaging (EACVI)
The European Association of Cardiovascular Imaging (EACVI) is a registered branch of the ESC. Its aim is to promote excellence in clinical diagnosis, research, technical development and education in cardiovascular ultrasound and other imaging modalities in Europe. It was formerly called the European Association of Echocardiography (EAE).

3 About the European Society of Cardiology (ESC)

The European Society of Cardiology (ESC) represents more than 75,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

Information for journalists attending EUROECHO and other Imaging Modalities 2012

EUROECHO and other Imaging Modalities 2012 takes place during 5-8 December in Athens, Greece, at the Megaron Athens International Conference Centre. The full scientific programme is available here http://spo.escardio.org/default.aspx?eevtid=55&hit=highlight-on

Registration is possible onsite, with a valid press card, assignment letter or three bylined articles and signed Embargo form.

A press working area will be available on the exhibition lower level (Level -1). Follow the Speakers Service Centre/Press Working Area signage. There will be no press conference, but a press kit will be available and a press coordinator onsite will assist the media with any EUROECHO and other Imaging Modalities 2012 spokespersons enquiries.

Authors:

ESC Press Office
Tel: On site at Athens: +33 6 22 41 84 92
Tel: +33 (0) 4 92 94 8627
Tel: +33 (0) 4 92 94 7756
Email: press@escardio.org

ESC Press Office | EurekAlert!
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Study points to new drug target in fight against cancer
19.09.2019 | Rice University

nachricht Researchers develop tumour growth roadmap
19.09.2019 | Universität Leipzig

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nervenzellen feuern Hirntumorzellen zum Wachstum an

Heidelberger Wissenschaftler und Ärzte beschreiben aktuell im Fachjournal „Nature“, wie Nervenzellen des Gehirns mit aggressiven Glioblastomen in Verbindung treten und so das Tumorwachstum fördern / Mechanismus der Tumor-Aktivierung liefert Ansatzpunkte für klinische Studien

Nervenzellen geben ihre Signale über Synapsen – feine Zellausläufer mit Kontaktknöpfchen, die der nächsten Nervenzelle aufliegen – untereinander weiter....

Im Focus: Stevens team closes in on 'holy grail' of room temperature quantum computing chips

Photons interact on chip-based system with unprecedented efficiency

To process information, photons must interact. However, these tiny packets of light want nothing to do with each other, each passing by without altering the...

Im Focus: Happy hour für die zeitaufgelöste Kristallographie

Ein Forschungsteam vom Max-Planck-Institut für Struktur und Dynamik der Materie (MPSD), der Universität Hamburg und dem European Molecular Biology Laboratory (EMBL) hat eine neue Methode entwickelt, um Biomoleküle bei der Arbeit zu beobachten. Sie macht es bedeutend einfacher, enzymatische Reaktionen auszulösen, da hierzu ein Cocktail aus kleinen Flüssigkeitsmengen und Proteinkristallen angewandt wird. Ab dem Zeitpunkt des Mischens werden die Proteinstrukturen in definierten Abständen bestimmt. Mit der dadurch entstehenden Zeitraffersequenz können nun die Bewegungen der biologischen Moleküle abgebildet werden.

Die Funktionen von Biomolekülen werden nicht nur durch ihre molekularen Strukturen, sondern auch durch deren Veränderungen bestimmt. Mittels der...

Im Focus: Happy hour for time-resolved crystallography

Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.

The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.

Im Focus: Modulare OLED-Leuchtstreifen

Das Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP, ein Anbieter von Forschung und Entwicklungsdienstleistungen auf dem Gebiet der organischen Elektronik, stellt auf dem International Symposium on Automotive Lighting 2019 (ISAL), vom 23. bis 25. September 2019, in Darmstadt, am Stand Nr. 37 erstmals OLED-Leuchtstreifen beliebiger Länge mit Zusatzfunktionalitäten vor.

Leuchtstreifen für das Innenraumdesign kennt inzwischen nahezu jeder. LED-Streifen sind als Meterware im Baumarkt um die Ecke erhältlich und ebenso oft als...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

VideoLinks
Industrie & Wirtschaft
Veranstaltungen

92. Neurologie-Kongress: Mehr als 6500 Neurologen in Stuttgart erwartet

20.09.2019 | Veranstaltungen

Frische Ideen zur Mobilität von morgen

20.09.2019 | Veranstaltungen

Thermodynamik – Energien der Zukunft

19.09.2019 | Veranstaltungen

VideoLinks
Wissenschaft & Forschung
Weitere VideoLinks im Überblick >>>
 
Aktuelle Beiträge

92. Neurologie-Kongress: Mehr als 6500 Neurologen in Stuttgart erwartet

20.09.2019 | Veranstaltungsnachrichten

Neue Strukturdaten zu Talin erklären Selbsthemmungs-Mechanismus

20.09.2019 | Biowissenschaften Chemie

Wie Algen pinke Pigmente herstellen

20.09.2019 | Biowissenschaften Chemie

Weitere B2B-VideoLinks
IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics