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Preservation solution for organ transplantation

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Ischemia-reperfusion injury contributes to allograft dysfunction and loss. Preservation solutions in organ transplantation are used for the preservation of allografts during transportation from the donor to the recipient in order to preserve organ function. Due to improved protective effects the present preservation solution is to confer prolonged survival and significantly enhanced function of the allograft. This may not only lead to improved quality of life, but also to a reduction in the number of patients awaiting transplantation. Preclinical studies led to the identification of the vasoprotecitve effects of statins associated with improved organ function following ischemiareperfusion. Statins are inhibitors of hydroxymethylglutaryl-coenzymA-reductase- Inhibitoren that are approved for lowering serum cholesterol levels. Statins exhibit several ideal properties for their use in organ transplantation, i.e. reduction of oxidative stress, improvement of endothelial function. Moreover, statins increase the bioavailability of NO that causes vasodilatation and thus improves blood flow. Two compounds of the statin family were identified to be appropriate for the use in preservation solutions, pravastatin und simvastatin. Both compounds are not subject to patent protection. Therefore, production is easy and cost effective. Moreover, statins have been introduced to the market many years ago and there is a large body of experience in other indications.

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