Using positron emission tomography combined with computed tomography (PET/CT), researchers were able to detect physiological evidence of chemo brain, a common side effect in patients undergoing chemotherapy for cancer treatment.
"The chemo brain phenomenon is described as 'mental fog' and 'loss of coping skills' by patients who receive chemotherapy," said Rachel A. Lagos, D.O., diagnostic radiology resident at the West Virginia University School of Medicine and West Virginia University Hospitals in Morgantown, W.V. "Because this is such a common patient complaint, healthcare providers have generically referred to its occurrence as 'chemo brain' for more than two decades."
While the complaint may be common, the cause of chemo brain phenomenon has been difficult to pinpoint. Some prior studies using magnetic resonance imaging (MRI) have found small changes in brain volume after chemotherapy, but no definitive link has been found.
Instead of studying chemotherapy's effect on the brain's appearance, Dr. Lagos and colleagues set out to identify its effect on brain function. By using PET/CT, they were able to assess changes to the brain's metabolism after chemotherapy.
"When we looked at the results, we were surprised at how obvious the changes were," Dr. Lagos said. "Chemo brain phenomenon is more than a feeling. It is not depression. It is a change in brain function observable on PET/CT brain imaging."
For the study, Dr. Lagos and colleagues analyzed PET/CT brain imaging results from 128 patients who had undergone chemotherapy for breast cancer. They used special software to help discern differences in brain metabolism before and after chemotherapy. Results were correlated with patient history, neurologic examinations and chemotherapy regimens.
PET/CT results demonstrated statistically significant decreases in regional brain metabolism that were closely associated with symptoms of chemo brain phenomenon.
"The study shows that there are specific areas of the brain that use less energy following chemotherapy," Dr. Lagos said. "These brain areas are the ones known to be responsible for planning and prioritizing."
Dr. Lagos believes that PET/CT could be used to help facilitate clinical diagnosis and allow for earlier intervention.
Research has already shown that patients with chemo brain can benefit from the assistance of nutritionists, exercise therapists, massage therapists and counselors. In one study, cancer patients receiving chemotherapy complained of losing their ability to prepare family meals.
"When the researchers provided these patients with written and planned menus for each meal, the women were able to buy the groceries, prepare the meals and enjoy them with their families," Dr. Lagos said.
Dr. Lagos and her fellow researchers hope that future studies will lead the way to better treatment for patients experiencing this often debilitating condition.
"The next step is to establish a prospective study that begins assessing new patients at the time of cancer diagnosis," she said. "The prospective study has the potential to establish an understanding of the change in brain neurotransmitters during chemotherapy, which may lead to improved treatment or prevention."
Coauthors are Jame Abraham, M.D., Gary Marano, M.D., Marc Haut, Ph.D., and Sara Kurian, M.S.
Note: Copies of RSNA 2012 news releases and electronic images will be available online at RSNA.org/press12 beginning Monday, Nov. 26.
RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)
Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.
For patient-friendly information on PET/CT, visit RadiologyInfo.org.
Malaria Already Endemic in the Mediterranean by the Roman Period
27.07.2017 | Universität Zürich
Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern
Quantenphysiker um Oriol Romero-Isart haben einen einfachen Aufbau entworfen, mit dem theoretisch beliebig stark fokussierte elektromagnetische Felder erzeugt werden können. Anwendung finden könnte das neue Verfahren zum Beispiel in der Mikroskopie oder für besonders empfindliche Sensoren.
Mikrowellen, Wärmestrahlung, Licht und Röntgenstrahlung sind Beispiele für elektromagnetische Wellen. Für viele Anwendungen ist es notwendig, diese Strahlung...
Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.
Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...
Das menschliche Gehirn besteht aus etwa hundert Milliarden Nervenzellen. Informationen zwischen ihnen werden über ein komplexes Netzwerk aus Nervenfasern übermittelt. Verdrahtet werden die meisten dieser Verbindungen vor der Geburt nach einem genetischen Bauplan, also ohne dass äußere Einflüsse eine Rolle spielen. Mehr darüber, wie das Navigationssystem funktioniert, das die Axone beim Wachstum leitet, haben jetzt Forscher des Karlsruher Instituts für Technologie (KIT) herausgefunden. Das berichten sie im Fachmagazin eLife.
Die Gesamtlänge des Nervenfasernetzes im Gehirn beträgt etwa 500.000 Kilometer, mehr als die Entfernung zwischen Erde und Mond. Damit es beim Verdrahten der...
Starke Licht-Materie-Kopplung in diesen halbleitenden Röhrchen könnte zu elektrisch gepumpten Lasern führen
Auch durch Anregung mit Strom ist die Erzeugung von leuchtenden Quasiteilchen aus Licht und Materie in halbleitenden Kohlenstoff-Nanoröhrchen möglich....
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
26.07.2017 | Veranstaltungen
26.07.2017 | Veranstaltungen
25.07.2017 | Veranstaltungen
27.07.2017 | Biowissenschaften Chemie
27.07.2017 | Unternehmensmeldung
27.07.2017 | Biowissenschaften Chemie