Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Researchers explore connection between popular pain relievers, bladder cancer

08.11.2012
Duration of ibuprofen use may be related to a reduced risk, especially in those with certain genetic marker

Dartmouth researchers have found that duration of ibuprofen use was associated with a reduced risk of bladder cancer in patients in northern New England, which has a high mortality rate of this disease.

In a 2012 collaborative project with the National Cancer Institute, Margaret Karagas, PhD, co-director, Cancer Epidemiology & Chemoprevention program at Norris Cotton Cancer Center, and Professor of Community and Family Medicine at the Geisel School of Medicine at Dartmouth, and Richard Waddell, D.Sc, Research Assistant Professor of Medicine at the Geisel School of Medicine, looked for connections between ibuprofen use and bladder cancer.

Bladder cancer and ibuprofen use

Karagas did an earlier study on the relationship between bladder cancer and nonsteroidal anti-inflammatory drugs (NSAIDs) usage in New Hampshire. The new study included patients in Vermont and Maine. Researchers enrolled 1,171 participants newly diagnosed with bladder cancer and 1,418 participants who did not have bladder cancer. Karagas also added a genetic component looking at thirty-nine genes related to NSAID metabolism and studied a new class of NSAIDs known as selective cyclooxygenase (COX-2) inhibitors, such as celecoxib (Celebrex). Their results were published in the International Journal of Cancer (June 2012).

Those with specific genetic traits appear to have reduced risk

The findings in the recent study suggest that "regular use of nonaspirin nonselective NSAIDs, particularly ibuprofen, may reduce bladder cancer risk, especially among regular users for 10 years or more." However, the study also notes that observed reduction in risk was specific to individuals carrying a specific allele (or variant of a gene) related to NSAID metabolism.

Findings suggest further study needed for newer prescription pain reliever

For Karagas one of the novel findings was a trend of an increased risk of bladder cancer for those using selective COX-2 inhibitors, especially celocoxib (Celebrex). Karagas warns against leaping to any conclusions, noting, "further investigation is needed."

Karagas also stresses that this study "does not make any recommendations. It does not, in any way, suggest that patients begin taking ibuprofen as a prophylactic measure against bladder cancer, nor should patients go off any medicine prescribed by their doctor."

This research study was funded by the National Institutes of Health Grant number: N02-CP-01037

About Norris Cotton Cancer Center at Dartmouth-Hitchcock

Norris Cotton Cancer Center combines advanced cancer research at Dartmouth College and the Geisel School of Medicine at Dartmouth with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center, at Dartmouth-Hitchcock regional locations in Manchester, Nashua, and Keene, NH, and St. Johnsbury, VT, and at 12 partner hospitals throughout New Hampshire and Vermont. It is one of 41 centers nationwide to earn the National Cancer Institute's "Comprehensive Cancer Center" designation. Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at cancer.dartmouth.edu

Donna Dubuc | EurekAlert!
Further information:
http://www.hitchcock.org
http://cancer.dartmouth.edu

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Vorstoß ins Innere der Atome

Mit Hilfe einer neuen Lasertechnologie haben es Physiker vom Labor für Attosekundenphysik der LMU und des MPQ geschafft, Attosekunden-Lichtblitze mit hoher Intensität und Photonenenergie zu produzieren. Damit konnten sie erstmals die Interaktion mehrere Photonen in einem Attosekundenpuls mit Elektronen aus einer inneren atomaren Schale beobachten konnten.

Wer die ultraschnelle Bewegung von Elektronen in inneren atomaren Schalen beobachten möchte, der benötigt ultrakurze und intensive Lichtblitze bei genügend...

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

Eine Gruppe von Forschern um Andrea Cavalleri am Max-Planck-Institut für Struktur und Dynamik der Materie (MPSD) in Hamburg hat eine Methode demonstriert, die es erlaubt die interatomaren Kräfte eines Festkörpers detailliert auszumessen. Ihr Artikel Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, nun online in Nature veröffentlich, erläutert, wie Terahertz-Laserpulse die Atome eines Festkörpers zu extrem hohen Auslenkungen treiben können.

Die zeitaufgelöste Messung der sehr unkonventionellen atomaren Bewegungen, die einer Anregung mit extrem starken Lichtpulsen folgen, ermöglichte es der...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Verlässliche Quantencomputer entwickeln

Internationalem Forschungsteam gelingt wichtiger Schritt auf dem Weg zur Lösung von Zertifizierungsproblemen

Quantencomputer sollen künftig algorithmische Probleme lösen, die selbst die größten klassischen Superrechner überfordern. Doch wie lässt sich prüfen, dass der...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

VideoLinks
Industrie & Wirtschaft
Veranstaltungen

Von festen Körpern und Philosophen

23.02.2018 | Veranstaltungen

Spannungsfeld Elektromobilität

23.02.2018 | Veranstaltungen

DFG unterstützt Kongresse und Tagungen - April 2018

21.02.2018 | Veranstaltungen

VideoLinks
Wissenschaft & Forschung
Weitere VideoLinks im Überblick >>>
 
Aktuelle Beiträge

Vorstoß ins Innere der Atome

23.02.2018 | Physik Astronomie

Wirt oder Gast? Proteomik gibt neue Aufschlüsse über Reaktion von Rifforganismen auf Umweltstress

23.02.2018 | Biowissenschaften Chemie

Wie Zellen unterschiedlich auf Stress reagieren

23.02.2018 | Biowissenschaften Chemie

Weitere B2B-VideoLinks
IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics