Irritable bowel syndrome (IBS) belongs to the most widespread diseases in Western countries, causing up to sixty per cent of the workload of gastrointestinal physicians.
One of the most frequent symptoms of IBS is bloating, which reduces quality of life considerably as patients perceive it as particularly bothersome. For quite a long time, IBS was believed to be a primarily psychological condition.
"Contrary to this view, recent findings suggest that IBS is linked to clearly detectable gut microbiota alterations. Additionally, bloating can be related to specific kinds of diet, thus opening up promising paths towards an efficient disease management," says Professor Giovanni Barbara (University of Bologna, Italy).
This was one of the topics presented at the Gut Microbiota for Health World Summit in Miami, FL, USA. On March 8-9, 2014, internationally leading experts discussed the latest advances in gut microbiota research and its impact on health.
IBS is one of the most common gastrointestinal disorders, causing several symptoms, which include abdominal pain, bowel movements that cause discomfort, and — in nearly all patients — bloating. IBS affects up to 20 percent of the population in Western countries. This condition represents up to 10 percent of the workload of family physicians and up to 60 per cent of that of gastroenterology practitioners. Within the range of IBS troubles, it is bloating that bothers patients most.
A microbiota-based condition
For quite a long time, not only bloating, but IBS in general was frequently perceived as a mainly psychological condition, mostly affecting young, predominantly female and anxious patients with no detectable abnormalities in their bowels. Consequently, the disease burden was often attributed to an imaginary disorder, and the treatment was far from satisfactory.
"Thanks to new diagnostic insights and a rapidly growing knowledge about the role and function of the microbial communities living inside our guts, our view on IBS and its causes has changed considerably," says Prof. Barbara, President of the European Society of Neurogastroenterology and Motility (ESNM). According to him, there is a lot of evidence showing that IBS is associated with an imbalanced composition of the gut microbiota. This means that the system of checks and balances between beneficial and potentially harmful bacteria, which characterizes a healthy gut microbiota, is disturbed in IBS patients.
"Probably the best example of this interaction is the discovery that IBS symptoms develop in up to 10 percent of previously healthy subjects after a single episode of gastroenteritis caused by an infection through bacterial pathogens like Salmonella, Shighella or Campylobacter, which can severely disrupt the microbiota balance," says Prof. Barbara. An additional problem results from the fact that not only infections, but also the antibiotics that are used as a remedy, may increase the risk for IBS, as they, too, can alter the gut microbiota in a negative way.
Nutrition is key
Another important factor is nutrition. Food that is rich in carbohydrates, particularly fiber, tends to produce larger amounts of gas than a diet without these ingredients. In some individuals, this might lead to repeated bloating and flatulence. The potentially negative impact of this kind of nutrition applies in particular to individuals who already suffer from IBS. Recent studies show that such a "flatulogenic" diet (for example, bread, cereals and pastries made of whole wheat, and beans, soy beans, corn, peas, Brussels' sprouts, cauliflower, broccoli, cabbage, celery, onions, leek, garlic, artichokes, figs, peaches, grapes and prunes) induces profound changes in the microbiota of IBS patients, thus prolonging and increasing the symptoms. However, at the same time, the gut microbiota of healthy subjects remained stable and unaffected by this kind of diet.1
"On the other hand, we now know for sure that diets containing low fiber content improve these symptoms significantly. Recent research results suggest that, compared to a normal Western diet, a diet low in so-called FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) reduces symptoms of IBS, including bloating, pain and passage of wind," says Prof. Barbara.
Another interesting observation Prof. Barbara points to is that those IBS patients who have several clear-cut gut symptoms have also more profound changes in their gut microbiota, as compared to other patients whose bowel physiology is less disturbed, but instead combined with mood disorders. This suggests that the troubles of the second group are more socially grounded and mood-related, whereas the condition of the patients belonging to the first group is predominantly physiologically based — IBS proper, so to speak.
What further developments can doctors and patients expect? "It is amazing to see how quickly gut microbiota research has gained center stage within gastroenterology in the course of the past few years," says Prof. Barbara. "This is due to its crucial role not only for IBS, but for gastrointestinal health in general. In order to further improve diagnosis and treatment, we have to identify more of the various functions of the intestinal bacteria. With regard to clinical applications, bacterial functions are even more important than their types."
The microbial communities that reside in the human gut and their impact on human health and disease are one of the most exciting new areas of research today. To address the most recent advances in this rapidly developing field, scientists and health-care professionals from all over the world came together at the Gut Microbiota for Health World Summit in Miami, Florida, USA, on March 8-9, 2014. The meeting was hosted by the Gut Microbiota & Health Section of the European Society of Neurogastroenterology and Motility (ESNM) and the American Gastroenterological Association (AGA) Institute, with the support of Danone.
1 Manichanh C, Eck A, Varela E, Roca J, Clemente JC, Gonzalez A, et al. Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet. Gut. 2013 Jun 13. PubMed PMID: 23766444. Epub 2013/06/15. Eng.
About the Gut Microbiota For Health Experts Exchange website
The http://www.gutmicrobiotaforhealth.com Experts Exchange, provided by the Gut Microbiota & Health Section of ESNM, is an online platform for health-care professionals, scientists, and other people interested in the field. Thanks to being an open, independent and participatory medium, this digital service enables a scientific debate in the field of gut microbiota.
Connected to http://www.gutmicrobiotaforhealth.com, the Twitter account @GMFHx, animated by experts, for experts from the medical and scientific community, actively contributes to the online exchanges about the gut microbiota. Follow @GMFHx on Twitter. You can follow the Twitter coverage of the event using #GMFH2014
About the Gut Microbiota & Health Section of ESNM
ESNM stands for the European Society of Neurogastroenterology and Motility, a member of United European Gastroenterology (UEG). The mission of the ESNM is to defend the interests of all professionals in Europe involved in the study of neurobiology and pathophysiology of gastrointestinal function. The Gut Microbiota & Health Section was set up to increase recognition of the links between the gut microbiota and human health, to spread knowledge and to raise interest in the subject. The Gut Microbiota & Health Section is open to professionals, researchers, and practitioners from all fields related to gut microbiota and health. http://www.esnm.eu/gut_health/gut_micro_health.php?navId=68
About the AGA
The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include more than 16,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programmes of the organisation. http://www.gastro.org
About Danone and Gut Microbiota for Health
Danone's conviction is that food plays an essential role in human health namely through the impact that the gut microbiota may have on health. That is why Danone supports the Gut Microbiota for Health World Summit and Experts Exchange web platform with the aim to encourage research and increase knowledge in this promising area, in line with its mission to "bring health through food to as many people as possible". http://www.danone.com
Aimee Frank | EurekAlert!
Medikamente mildern Mukoviszidose
23.01.2018 | Medizinische Hochschule Hannover
Dreifachblockade am Glioblastom
23.01.2018 | Julius-Maximilians-Universität Würzburg
Physiker haben eine lichtmikroskopische Technik entwickelt, mit der sich Atome auf der Nanoskala abbilden lassen. Das neue Verfahren ermöglicht insbesondere, Quantenpunkte in einem Halbleiter-Chip bildlich darzustellen. Dies berichten die Wissenschaftler des Departements Physik und des Swiss Nanoscience Institute der Universität Basel zusammen mit Kollegen der Universität Bochum in «Nature Photonics».
Mikroskope machen Strukturen sichtbar, die dem menschlichen Auge sonst verborgen blieben. Einzelne Moleküle und Atome, die nur Bruchteile eines Nanometers...
Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
Am 31. Januar 2018 fallen zum ersten Mal seit dem 30. Dezember 1982 "Supermond" (ein Vollmond in Erdnähe), "Blutmond" (eine totale Mondfinsternis) und "Blue Moon" (ein zweiter Vollmond im Kalendermonat) zusammen - Beobachter im deutschen Sprachraum verpassen allerdings die sichtbaren Phasen der Mondfinsternis.
Nach den letzten drei Vollmonden am 4. November 2017, 3. Dezember 2017 und 2. Januar 2018 ist auch der bevorstehende Vollmond am 31. Januar 2018 ein...
Auf dem Weg zum intelligenten Labor präsentieren Physiker der Universitäten Innsbruck und Wien ein lernfähiges Programm, das eigenständig Quantenexperimente entwirft. In ersten Versuchen hat das System selbständig experimentelle Techniken (wieder)entdeckt, die heute in modernen quantenoptischen Labors Standard sind. Dies zeigt, dass Maschinen in Zukunft auch eine kreativ unterstützende Rolle in der Forschung einnehmen könnten.
In unseren Taschen stecken Smartphones, auf den Straßen fahren intelligente Autos, Experimente im Forschungslabor aber werden immer noch ausschließlich von...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
23.01.2018 | Veranstaltungen
23.01.2018 | Veranstaltungen
23.01.2018 | Veranstaltungen
23.01.2018 | Biowissenschaften Chemie
23.01.2018 | Maschinenbau
23.01.2018 | Biowissenschaften Chemie