Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

New hormone therapy shows promise for menopausal symptoms in animal model

13.12.2012
Findings reported by Wake Forest Baptist investigators

Investigators at Wake Forest Baptist Medical Center have concluded research on a new postmenopausal hormone therapy that shows promise as an effective treatment for menopausal symptoms and the prevention of osteoporosis without increasing the risk for heart disease or breast cancer.

Traditional forms of hormone therapy (HT) provide the benefits of symptom relief, prevention of osteoporosis and prevention of atherosclerosis, but increase the risk of uterine cancer (with estrogens alone) or breast cancer (with combined estrogens and progestins). Thus, the risk-benefit ratio of traditional HT is not ideal. Less potent plant-derived estrogens are relatively safe, but less effective. Selective estrogen receptor modulators (SERMs) provide both beneficial effects and adverse effects, but the ideal treatment has proven elusive, said J. Mark Cline, D.V.M., Ph.D., one of the co-authors.

The Wake Forest Baptist team worked in partnership with the pharmaceutical company Pfizer to explore a new strategy, termed a Tissue Selective Estrogen Combination (TSEC). Using this strategy, a conventional estrogen (CEE) was combined with a bone-protective SERM-like drug, bazedoxifene acetate (BZA), to produce a complementary pattern of tissue effects that maximize the benefits of HT while avoiding the risk. The study involved a 20-month randomized, parallel-arm trial – which has a comparison group and at least one new or active therapy group – in postmenopausal nonhuman primates, designed to determine the effect of TSEC treatment on the breast, uterus and cardiovascular system.

The TSEC strategy has been evaluated in the Selective estrogens, Menopause, And Response to Therapy (SMART) phase 3 trials involving more than 6,000 women. Cline said the Wake Forest Baptist nonhuman primate trials are important because they can address tissue responses directly, whereas studies in women use clinical outcomes that may require many years to provide conclusive results.

The Wake Forest Baptist findings are discussed in separate papers, both published recently in Menopause: The Journal of The North American Menopause Society.

Prior work by Cline in the 1990s demonstrated the adverse effect of a widely used estrogens and estrogen-progestin combination on the breast, a finding that was predictive of the breast cancer patterns later found in the Women's Health Initiative. In contrast to that finding, the TSEC strategy is anticipated to reduce breast cancer risk. "Remarkably, BZA overrides the adverse effects of CEE at the level of gene expression in the breast, suppressing abnormal tissue growth," Cline said.

Lead investigator Thomas B. Clarkson, D.V.M., is hopeful about the promise of this new approach. "The findings are encouraging for postmenopausal women," he said. "We believe that women can be given CEE along with BZA to protect against breast cancer and uterine cancer, without adversely affecting the cardiovascular system, but more research is necessary."

Other team members include: Kelly F. Ethun, D.V.M., Charles E. Wood, D.VM., Ph.D, Thomas C. Register, Ph.D, and Susan E. Appt, D.V.M., all of Wake Forest Baptist.

Wake Forest School of Medicine received an investigator-initiated grant to Clarkson from Pfizer to conduct the work described. Clarkson and Cline have been paid consultants for Pfizer. Appt is the principal investigator on a pending investigator-initiated proposal to Pfizer, related to further development of the TSEC approach.

Bonnie Davis | EurekAlert!
Further information:
http://www.wakehealth.edu

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Löschbare Tinte für den 3-D-Druck

Im 3-D-Druckverfahren durch Direktes Laserschreiben können Mikrometer-große Strukturen mit genau definierten Eigenschaften geschrieben werden. Forscher des Karlsruher Institus für Technologie (KIT) haben ein Verfahren entwickelt, durch das sich die 3-D-Tinte für die Drucker wieder ‚wegwischen‘ lässt. Die bis zu hundert Nanometer kleinen Strukturen lassen sich dadurch wiederholt auflösen und neu schreiben - ein Nanometer entspricht einem millionstel Millimeter. Die Entwicklung eröffnet der 3-D-Fertigungstechnik vielfältige neue Anwendungen, zum Beispiel in der Biologie oder Materialentwicklung.

Beim Direkten Laserschreiben erzeugt ein computergesteuerter, fokussierter Laserstrahl in einem Fotolack wie ein Stift die Struktur. „Eine Tinte zu entwickeln,...

Im Focus: Leichtbau serientauglich machen

Immer mehr Autobauer setzen auf Karosserieteile aus kohlenstofffaserverstärktem Kunststoff (CFK). Dennoch müssen Fertigungs- und Reparaturkosten weiter gesenkt werden, um CFK kostengünstig nutzbar zu machen. Das Laser Zentrum Hannover e.V. (LZH) hat daher zusammen mit der Volkswagen AG und fünf weiteren Partnern im Projekt HolQueSt 3D Laserprozesse zum automatisierten Besäumen, Bohren und Reparieren von dreidimensionalen Bauteilen entwickelt.

Automatisiert ablaufende Bearbeitungsprozesse sind die Grundlage, um CFK-Bauteile endgültig in die Serienproduktion zu bringen. Ausgerichtet an einem...

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Immunzellen helfen bei elektrischer Reizleitung im Herzen

Erstmals elektrische Kopplung von Muskelzellen und Makrophagen im Herzen nachgewiesen / Erkenntnisse könnten neue Therapieansätze bei Herzinfarkt und Herzrhythmus-Störungen ermöglichen / Publikation am 20. April 2017 in Cell

Makrophagen, auch Fresszellen genannt, sind Teil des Immunsystems und spielen eine wesentliche Rolle in der Abwehr von Krankheitserregern und bei der...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Forschungsexpedition „Meere und Ozeane“ mit dem Ausstellungsschiff MS Wissenschaft

24.04.2017 | Veranstaltungen

3. Bionik-Kongress Baden-Württemberg

24.04.2017 | Veranstaltungen

Smart-Data-Forschung auf dem Weg in die wirtschaftliche Praxis

21.04.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Phoenix Contact übernimmt Spezialisten für Netzleittechnik

24.04.2017 | Unternehmensmeldung

Phoenix Contact beteiligt sich an Berliner Start-up Unternehmen für Energiemanagement

24.04.2017 | Unternehmensmeldung

Phoenix Contact übernimmt Spezialisten für industrielle Kommunikationstechnik

24.04.2017 | Unternehmensmeldung