Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

High levels of vitamin D in plasma protects against bladder cancer

31.10.2012
With this study, which combines epidemiological and molecular data, researchers have identified a genetic route that vitamin D could use to prevent this type of cancer

High levels of vitamin D are associated with protection against bladder cancer, according to a multidisciplinary study coordinated by molecular biologists and epidemiologists from the Spanish National Cancer Research Centre (CNIO), the conclusions of which are being published today in the Journal of National Cancer Institute (JNCI) .

The study has been led by Núria Malats, head of the Genetic and Molecular Epidemiology Group, and Francisco X. Real, from the Epithelial Carcinogenesis Group, at the CNIO.

The authors of the study took blood samples from more than 2,000 individuals—including patients with bladder cancer and control subjects free from the disease—in 18 Spanish hospitals, making of this the largest study carried out to-date in this field. "We have seen that those subjects with the highest levels of 25(OH)D3, a stable form of vitamin D in the blood, are those who showed the lowest risk of suffering bladder cancer. These results indicate that high levels of this vitamin are associated with protection from the illness or, similarly, that low levels are associated with a higher risk of suffering from it", says Malats.

"We have also shown, using in vitro molecular analysis, that vitamin D regulates the expression of a protein—FGFR3—that takes part in the development of bladder cancer", adds Real.

According to the study, this protective effect is more obvious in those patients with more aggressive cancers. "We observe that high levels of vitamin D diminish, above all, the risk of developing invasive bladder cancer with low levels of FGFR3; which is to say those cancers with the highest probability of metastizing", says André FS Amaral, first author of the study.

The research results suggest that an increase in the dietary or supplementary intake of this vitamin, or via a controlled increase in sun exposure, might be beneficial for the patient in terms of prevention and treatment.

MORE THAN 11,000 NEW CASES EACH YEAR IN SPAIN

Bladder cancer represents a serious public health problem in many countries, especially Spain, where 11,000 new cases are registered each year, one of the highest rates anywhere in the world. In fact, it is the fourth most frequent type of tumour among Spanish males, after prostate, lung and colorectal cancers.

Following diagnosis, patients are continually observed with different follow-up techniques, among them cystoscopy, which requires the introduction of a small camera via the urethra to observe the bladder lining.

This type of follow-up affects the patients' quality of life and imposes heavy costs on healthcare authorities, thus further increasing the need to improve prevention strategies faced with this type of cancer.

Recent studies relate vitamin D levels with other types of cancer like breast or colon cancer. Despite this research, it is still not clearly understood which molecular routes are used by this vitamin to exercise its protective effect, or the role it plays in other types of tumours.

INTERNATIONAL COLLABORATION
The study took place within the EPICURO/Spanish Bladder Cancer Study, whose aims are to evaluate, among other aspects, both the genetic and non-genetic factors associated with the risk and prognosis for this tumour.

The EPICURO/Spanish Bladder Cancer Study began in 1997 as a collaborative project involving several Spanish institutions coordinated by the Instituto Hospital del Mar de Investigaciones Médicas (Barcelona), and the Division of Cancer Epidemiology and Genetics of the US National Cancer Institute.

Researcher Alberto Muñoz, from the CSIC's Biomedical Research Institute in Madrid has also participated in this specific study on vitamin D.

The research project has been funded by the World Cancer Research Fund (UK); the Intramural Research Program of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (US); the Fondo de Investigación Sanitaria, the Red Temática de Investigación Cooperativa en Cáncer, the AECC's Scientific Foundation, the Consolíder ONCOBIO project and the Madrid regional government in Spain.

Reference article:
Plasma 25-hydroxyvitamin D3 and bladder cancer risk according to tumor stage and FGFR3 status. André FS Amaral, Marinela Méndez-Pertuz, Alberto Muñoz, Debra T Silverman, Yves Allory, Manolis Kogevinas, Josep Lloreta, Nathaniel Rothman, Alfredo Carrato, Manuel Rivas del Fresno, Francisco X Real, and Núria Malats. Journal of National Cancer Institute (2012). doi: 10.1093/jnci/djs444

Nuria Noriega | EurekAlert!
Further information:
http://www.cnio.es

More articles from Health and Medicine:

nachricht Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Die schnellste lichtgetriebene Stromquelle der Welt

Die Stromregelung ist eine der wichtigsten Komponenten moderner Elektronik, denn über schnell angesteuerte Elektronenströme werden Daten und Signale übertragen. Die Ansprüche an die Schnelligkeit der Datenübertragung wachsen dabei beständig. In eine ganz neue Dimension der schnellen Stromregelung sind nun Wissenschaftler der Lehrstühle für Laserphysik und Angewandte Physik an der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) vorgedrungen. Ihnen ist es gelungen, im „Wundermaterial“ Graphen Elektronenströme innerhalb von einer Femtosekunde in die gewünschte Richtung zu lenken – eine Femtosekunde entspricht dabei dem millionsten Teil einer milliardstel Sekunde.

Der Trick: die Elektronen werden von einer einzigen Schwingung eines Lichtpulses angetrieben. Damit können sie den Vorgang um mehr als das Tausendfache im...

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: Effizientere und präzisere Kontakte dank Roboter-Kollaboration

Auf der diesjährigen productronica in München stellt das Fraunhofer-Institut für Lasertechnik ILT das Laser-Based Tape-Automated Bonding, kurz LaserTAB, vor: Die Aachener Experten zeigen, wie sich dank neuer Optik und Roboter-Unterstützung Batteriezellen und Leistungselektronik effizienter und präziser als bisher lasermikroschweißen lassen.

Auf eine geschickte Kombination von Roboter-Einsatz, Laserscanner mit selbstentwickelter neuer Optik und Prozessüberwachung setzt das Fraunhofer ILT aus Aachen.

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Im Spannungsfeld von Biologie und Modellierung

26.09.2017 | Veranstaltungen

Archaeopteryx, Klimawandel und Zugvögel: Deutsche Ornithologen-Gesellschaft tagt an der Uni Halle

26.09.2017 | Veranstaltungen

Unsere Arbeitswelt von morgen – Polarisierendes Thema beim 7. Unternehmertag der HNEE

26.09.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Mit künstlicher Intelligenz zum chemischen Fingerabdruck

26.09.2017 | Biowissenschaften Chemie

Eine detaillierte Waldkarte des blauen Planeten

26.09.2017 | Geowissenschaften

RWI/ISL-Containerumschlag-Index steigt weiter

26.09.2017 | Wirtschaft Finanzen