Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Growth factor aids stem cell regeneration after radiation damage

04.02.2013
Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters.

Reported in the Feb. 3, 2013, issue of the journal Nature Medicine, the researchers explored what had first appeared to be an anomaly among certain genetically modified mice with an abundance of epidermal growth factor in their bone marrow. The mice were protected from radiation damage, and the researchers questioned how this occurred.

"Epidermal growth factor was not known to stimulate hematopoiesis, which is the formation of blood components derived from hematopoietic stem cells," said senior author John Chute, M.D., a professor of medicine and professor of pharmacology and cancer biology at Duke University. "However, our studies demonstrate that the epidermal growth promotes hematopoietic stem cell growth and regeneration after injury."

Hematopoietic stem cells, which constantly churn out new blood and immune cells, are highly sensitive to radiation damage. Protecting these cells or improving their regeneration after injury could benefit patients who are undergoing bone marrow transplantation, plus others who suffer radiation injury from accidental environmental exposures such as the Japanese nuclear disaster in 2011.

The Duke researchers launched their investigation using mice specially bred with deletions of two genes that regulate the death of endothelial cells, which line the inner surface of blood vessels and are thought to regulate the fate of hematopoietic stem cells. Blood vessels and the hematopoietic system in these mice were less damaged when exposed to high doses of radiation, improving their survival.

An analysis of secretions from bone marrow endothelial cells of the protected mice showed that epidermal growth factor (EGF) was significantly elevated - up to 18-fold higher than what was found in the serum of control mice. The researchers then tested whether EGF could directly spur the growth of stem cells in irradiated bone marrow cultured in the lab. It did, with significant recovery of stem cells capable of repopulating transplanted mice.

Next, the Duke team tried the approach in mice using three different solutions of cells in animals undergoing bone marrow transplants. One group received regular bone marrow cells; a second group got bone marrow cells from donors that had been irradiated and treated with EGF; a third group got bone marrow cells from irradiated donors treated with saline.

The regular bone marrow cells proliferated well and had the highest rate of engraftment in the recipient mice. But mice that were transplanted with the cells from irradiated/EGF-treated donors had 20-fold higher engraftment rate than the third group.

Additional studies showed that EGF improved survival from a lethal radiation exposure, with 93 percent of mice surviving the radiation dose if they subsequently received treatment with EGF, compared to 53 percent surviving after treatment with a saline solution.

Chute said it appears that EGF works by repressing a protein called PUMA that normally triggers stem cell death following radiation exposure.

"We are just beginning to understand the mechanisms through which EGF promotes stem cell regeneration after radiation injury," Chute said. "This study suggests that EGF might have potential to accelerate the recovery of the blood system in patients treated with chemotherapy or radiation."

In addition to Chute, study authors include Phuong L. Doan, Heather A. Himburg, Katherine Helms, J. Lauren Russell, Emma Fixsen, Mamle Quarmyne, Jeffrey R. Harris, Divino Deoliviera, Julie M. Sullivan, Nelson J. Chao and David G. Kirsch.

The study was funded by the National Heart, Lung and Blood Institute (HL-086998-01); the National Institute of Allergy and Infectious Diseases (AI-067798-06, AI-067798-01); the National Institutes of Health (T32 HL0070757-33); the Barton Haynes Award and Duke University.

Sarah Avery | EurekAlert!
Further information:
http://www.duke.edu

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Starke IT-Sicherheit für das Auto der Zukunft – Forschungsverbund entwickelt neue Ansätze

Je mehr die Elektronik Autos lenkt, beschleunigt und bremst, desto wichtiger wird der Schutz vor Cyber-Angriffen. Deshalb erarbeiten 15 Partner aus Industrie und Wissenschaft in den kommenden drei Jahren neue Ansätze für die IT-Sicherheit im selbstfahrenden Auto. Das Verbundvorhaben unter dem Namen „Security For Connected, Autonomous Cars (SecForCARs) wird durch das Bundesministerium für Bildung und Forschung mit 7,2 Millionen Euro gefördert. Infineon leitet das Projekt.

Bereits heute bieten Fahrzeuge vielfältige Kommunikationsschnittstellen und immer mehr automatisierte Fahrfunktionen, wie beispielsweise Abstands- und...

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Mit Hilfe molekularer Schalter lassen sich künftig neuartige Bauelemente entwickeln

Einem Forscherteam unter Führung von Physikern der Technischen Universität München (TUM) ist es gelungen, spezielle Moleküle mit einer angelegten Spannung zwischen zwei strukturell unterschiedlichen Zuständen hin und her zu schalten. Derartige Nano-Schalter könnten Basis für neuartige Bauelemente sein, die auf Silizium basierende Komponenten durch organische Moleküle ersetzen.

Die Entwicklung neuer elektronischer Technologien fordert eine ständige Verkleinerung funktioneller Komponenten. Physikern der TU München ist es im Rahmen...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: GRACE Follow-On erfolgreich gestartet: Das Satelliten-Tandem dokumentiert den globalen Wandel

Die Satellitenmission GRACE-FO ist gestartet. Am 22. Mai um 21.47 Uhr (MESZ) hoben die beiden Satelliten des GFZ und der NASA an Bord einer Falcon-9-Rakete von der Vandenberg Air Force Base (Kalifornien) ab und wurden in eine polare Umlaufbahn gebracht. Dort nehmen sie in den kommenden Monaten ihre endgültige Position ein. Die NASA meldete 30 Minuten später, dass der Kontakt zu den Satelliten in ihrem Zielorbit erfolgreich hergestellt wurde. GRACE Follow-On wird das Erdschwerefeld und dessen räumliche und zeitliche Variationen sehr genau vermessen. Sie ermöglicht damit präzise Aussagen zum globalen Wandel, insbesondere zu Änderungen im Wasserhaushalt, etwa dem Verlust von Eismassen.

Potsdam, 22. Mai 2018: Die deutsch-amerikanische Satellitenmission GRACE-FO (Gravity Recovery And Climate Experiment Follow On) ist erfolgreich gestartet. Am...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

VideoLinks
Industrie & Wirtschaft
Veranstaltungen

Im Fokus: Klimaangepasste Pflanzen

25.05.2018 | Veranstaltungen

Größter Astronomie-Kongress kommt nach Wien

24.05.2018 | Veranstaltungen

22. Business Forum Qualität: Vom Smart Device bis zum Digital Twin

22.05.2018 | Veranstaltungen

VideoLinks
Wissenschaft & Forschung
Weitere VideoLinks im Überblick >>>
 
Aktuelle Beiträge

Berufsausbildung mit Zukunft

25.05.2018 | Unternehmensmeldung

Untersuchung der Zellmembran: Forscher entwickeln Stoff, der wichtigen Membranbestandteil nachahmt

25.05.2018 | Interdisziplinäre Forschung

Starke IT-Sicherheit für das Auto der Zukunft – Forschungsverbund entwickelt neue Ansätze

25.05.2018 | Informationstechnologie

Weitere B2B-VideoLinks
IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics