Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Painkillers show Alzheimer’s promise

08.11.2001



Ibuprofen could keep more than headaches at bay.
© SPL



More evidence is emerging that over-the-counter painkillers such as ibuprofen could form the basis of future treatments for Alzheimer’s disease. A new study suggests that some non-steroidal anti-inflammatory drugs (NSAIDs) block a process thought to cause the degenerative brain disease.

... mehr zu:
»Alzheimer »Cox »NSAID


In mice and in cultured human cells, certain NSAIDs prevent a harmful variety of a protein called amyloid from forming - instead the cells produce another amyloid. Many believe that Alzheimer’s results when clumps - called plaques - of the harmful amyloid accumulate in the brain.

Better still, the NSAIDs do not seem to effect other brain proteins. Existing Alzheimer’s drugs interfere with all amyloid proteins and other molecules in the brain, causing undesirable side-effects.

"This is the first known set of compounds that inhibit the pathogenic [amyloid]," says Edward Koo, a neuroscientist at the University of California, San Diego, who led the study1.

Although promising, experimental success in cell cultures and mice doesn’t always translate to humans, Koo warns. "This doesn’t mean it’s safe to take these drugs to treat Alzheimer’s," he says. A human would have to consume the equivalent of 16 ibuprofen tablets a day before any effect was seen - far more than the recommended safe dose.

But by looking for compounds that are similar to NSAIDs, Koo hopes to produce a new Alzheimer’s drug with anti-plaque properties but none of the toxic side-effects of either NSAIDs or current Alzheimer’s drugs.

It may be a bit more difficult than that, warns Michael Garavito, a molecular biologist at Michigan State University in East Lansing. "This tantalizing research makes it worthwhile exploring this pathway further," he says, but he doubts that researchers will easily uncover the NSAID connection until Alzheimer’s itself is better understood. "It’s still up in the air as to what is the root cause of Alzheimer’s," he says.

Lack of inflammation

There has long been tantalizing evidence that NSAIDs might alleviate Alzheimer’s disease. Occasionally, Alzheimer’s symptoms are reduced in elderly patients who take NSAIDs to ease pain and inflammatory diseases such as arthritis.

"There’s a major controversy as to what is actually happening," says Garavito. Many NSAIDs, such as aspirin, have no effect on Alzheimer’s symptoms. Others, such as ibuprofen, show some effect but only at high, potentially toxic doses.

The plaque-scotching signs seen by Koo’s team do not seem to be due to the anti-inflammatory properties of NSAIDs. These medicines inhibit inflammation by inducing cooxygenase (COX) enzymes, but the NSAIDs still had their anti-plaque effect in mutant cells that lack COX, the team found.

References

  1. Weggen, S. et al. A subset of NSAIDs lower amyloidogenic Aß42 independently of cyclooxygenase activity. Nature, 414, 212 - 216, (2001).


TOM CLARKE | © Nature News Service
Weitere Informationen:
http://www.nature.com/nsu/011108/011108-10.html

Weitere Berichte zu: Alzheimer Cox NSAID

Weitere Nachrichten aus der Kategorie Medizin Gesundheit:

nachricht Bei Notfällen wie Herzinfarkt und Schlaganfall immer den Notruf 112 wählen: Jede Minute zählt!
22.06.2017 | Deutsche Herzstiftung e.V./Deutsche Stiftung für Herzforschung

nachricht Tropenviren bald auch in Europa? Bayreuther Forscher untersuchen Folgen des Klimawandels
21.06.2017 | Universität Bayreuth

Alle Nachrichten aus der Kategorie: Medizin Gesundheit >>>

Die aktuellsten Pressemeldungen zum Suchbegriff Innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Klima-Satellit: Mit robuster Lasertechnik Methan auf der Spur

Hitzewellen in der Arktis, längere Vegetationsperioden in Europa, schwere Überschwemmungen in Westafrika – mit Hilfe des deutsch-französischen Satelliten MERLIN wollen Wissenschaftler ab 2021 die Emissionen des Treibhausgases Methan auf der Erde erforschen. Möglich macht das ein neues robustes Lasersystem des Fraunhofer-Instituts für Lasertechnologie ILT in Aachen, das eine bisher unerreichte Messgenauigkeit erzielt.

Methan entsteht unter anderem bei Fäulnisprozessen. Es ist 25-mal wirksamer als das klimaschädliche Kohlendioxid, kommt in der Erdatmosphäre aber lange nicht...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: Die Schweiz in Pole-Position in der neuen ESA-Mission

Die Europäische Weltraumagentur ESA gab heute grünes Licht für die industrielle Produktion von PLATO, der grössten europäischen wissenschaftlichen Mission zu Exoplaneten. Partner dieser Mission sind die Universitäten Bern und Genf.

Die Europäische Weltraumagentur ESA lanciert heute PLATO (PLAnetary Transits and Oscillation of stars), die grösste europäische wissenschaftliche Mission zur...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Von Batterieforschung bis Optoelektronik

23.06.2017 | Veranstaltungen

10. HDT-Tagung: Elektrische Antriebstechnologie für Hybrid- und Elektrofahrzeuge

22.06.2017 | Veranstaltungen

„Fit für die Industrie 4.0“ – Tagung von Hochschule Darmstadt und Schader-Stiftung am 27. Juni

22.06.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Radioaktive Elemente in Cassiopeia A liefern Hinweise auf Neutrinos als Ursache der Supernova-Explosion

23.06.2017 | Physik Astronomie

Dünenökosysteme modellieren

23.06.2017 | Ökologie Umwelt- Naturschutz

Makro-Mikrowelle macht Leichtbau für Luft- und Raumfahrt effizienter

23.06.2017 | Materialwissenschaften