In recent decades bioahesives, tissue sealants and hemostatic agents became the favored products to control bleeding and promote tissue healing after surgery. However, many of them have side effects or other problems, including an inability to perform well on wet tissue.
"To solve this medical problem, we looked at nature," said Jian Yang, associate professor of bioengineering at Penn State. "There are sea creatures, like the mussel, that can stick on rocks and on ships in the ocean. They can hold on tightly without getting flushed away by the waves because the mussel can make a very powerful adhesive protein. We looked at the chemical structure of that kind of adhesive protein."
Yang, along with University of Texas-Arlington researchers Mohammadreza Mehdizadeh, Hong Weng, Dipendra Gyawali and Liping Tang, took the biological information and developed a wholly synthetic family of adhesives. They incorporated the chemical structure from the mussel's adhesive protein into the design of an injectable synthetic polymer. The bioahesives, called iCMBAs, adhere well in wet environments, have controlled degradability, improved biocompatibility and lower manufacturing costs, putting them a step above current products such as fibrin glue and cyanoacrylate adhesives.
Fibrin glues are fast acting and biodegradable but have relatively poor adhesion strength. They may also carry risk of blood-borne disease transmission and have the potential for allergic reactions due to animal-based ingredients. Cyanoacrylate adhesives -- super glues -- offer strong adhesion, rapid setting time and strong adhesion to tissue, but they degrade slowly and may cause toxicity, often limiting their use to external applications.
Additionally, neither product is effective when used on wet tissue, a requirement of internal organ surgery, nor are there any current commercially available tissue adhesives or sealants appropriate for both external and internal use.
The researchers tested the newly developed iCMBAs on rats, using the adhesive and finger clamping to close three wounds for two minutes. Three other wounds were closed using sutures. The researchers reported their findings in a recent issue of Biomaterials.
The iCMBAs provided 2.5 to 8.0 times stronger adhesion in wet tissue conditions compared to fibrin glue. They also stopped bleeding instantly, facilitated wound healing, closed wounds without the use of sutures and offered controllable degradation.
"If you want the material to stay there for one week, we can control the polymer to degrade in one week," said Yang. "If you want the material to stay in the wound for more than a month, we can control the synthesis to make the materials degrade in one month."
The iCMBAs are also non-toxic, and because they are fully synthetic, they are unlikely to cause allergic reactions. Side effects were limited to mild inflammation.
"If you put any synthetic materials into your body," said Yang, "the body will generate some inflammation."
The researchers are now working on improving the formula.
"We are still optimizing our formulation," said Yang. "We are still trying to make the adhesion strength even stronger" to expand its use for things like broken bones where strong adhesion is tremendously important.
The researchers are also looking at adding in components that could control infection.
"We can introduce another component with anti-microbial properties, so it can do two functions at once," said Yang.
The iCMBAs could eventually be used in a wide range of surgical disciplines from suture and staple replacement to tissue grafts to treat hernias, ulcers and burns.
"There are so many applications that you can use this glue for to help in surgery," said Yang.
A'ndrea Elyse Messer | EurekAlert!
Semiconductor nanoparticles show high luminescence in a polymer matrix
02.10.2015 | Toyohashi University of Technology
A necklace of fractional vortices
02.10.2015 | Chalmers University of Technology
Das Laser Zentrum Hannover e.V. (LZH) zeigt vom 6. bis zum 8. Oktober 2015 auf der LABVOLUTION in Hannover in Halle 9, Stand E67/09 wie laserbasierte Technologien zum Labor der Zukunft beitragen können. Als Teil des Musterlabors smartLAB präsentiert das LZH, wie die additive Fertigung, besser bekannt als 3D-Druck, Versuchsaufbauten flexibler gestalten kann.
Zwölf Partner aus Wissenschaft und Industrie stellen auf der Sonderausstellung smartLAB ein intelligentes und innovatives Musterlabor vor. Teil dieses...
The Laser Zentrum Hannover e.V. (LZH) will present how laser-based technologies can contribute to the laboratory of the future at the LABVOLUTION in Hannover in Hall 9, Stand E67/09, from October 6th to 8th, 2015. As a part of the model lab smartLAB, the LZH is showing how additive manufacturing, better known as 3-D printing, can make experimental setups more flexible.
Twelve partners from science and industry are presenting an intelligent and innovative model lab at the special display smartLAB. A part of this intelligent...
Before embarking on a transcontinental journey, jet airplanes fill up with tens of thousands of gallons of fuel. In the event of a crash, such large quantities of fuel increase the severity of an explosion upon impact.
Researchers at Caltech and JPL have discovered a polymeric fuel additive that can reduce the intensity of postimpact explosions that occur during accidents and...
02.10.2015 | Veranstaltungen
02.10.2015 | Veranstaltungen
01.10.2015 | Veranstaltungen
02.10.2015 | Messenachrichten
02.10.2015 | Architektur Bauwesen
02.10.2015 | Materialwissenschaften