Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

EU Grant Awarded for Dementia Research - Max Planck Researchers receive 13.9 Million Euros from EU

19.12.2012
Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's disease and amyotrophic lateral sclerosis (ALS) are characterized by toxic protein aggregates in certain regions of the brain and nerve cells.
The objective of the project of F.-Ulrich Hartl, Wolfgang Baumeister, Rüdiger Klein and Matthias Mann is to elucidate just how this aggregation process is linked to cytotoxicity and cell death. For their project, the four directors of the Max Planck Institutes of Biochemistry and of Neurobiology in Martinsried near Munich, Germany, have now been awarded a Synergy Grant of the European Research Council (ERC) in the amount of 13.9 million euros.

An estimated 35.6 million people across the globe suffer from dementia or neurodegenerative disease. According to the World Health Organization (WHO), this number will almost double in the next twenty years. Without effective treatments, in particular the developed countries with their aging populations will face a huge medical and socio-economic problem.

Age-related neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis (ALS). All four diseases are characterized by toxic protein aggregates in specific brain regions and nerve cells. Although different proteins may form these aggregates, they always tend to form fibrous structures (amyloid fibrils). How these aggregates are associated with the observed cytotoxicity and death of the nerve cells is still unclear. In a large-scale project, the four Max Planck directors will seek to find the common causes and consequences of the protein aggregations using a trans-disciplinary approach combining cellular biochemistry, proteomics and cryo-electron tomography.

The aim of the project is to elucidate the basic mechanisms of aggregation toxicity of amyloid-like proteins in cell cultures and in mouse models of neurodegenerative diseases. Understanding these mechanisms will be invaluable in developing novel therapeutic strategies for some of the most debilitating diseases of our time. The European Research Council highlighted the importance of the project by awarding it the ERC Synergy Grant worth 13.9 million euros. The project of the Max Planck scientists is one of eleven projects to receive the award. Overall, 710 project proposals were submitted to the European Research Council for this very first round of ERC Synergy Grants.

The importance of the project, the scientific excellence of the four applicants and the optimal complementarity of their research areas were the main factors contributing to the positive decision of the European Research Council.

Prof. Dr. F.-Ulrich Hartl has been director at the MPI of Biochemistry since 1997. His department studies how proteins acquire their three-dimensional structure. In neurodegenerative diseases such as Alzheimer’s, the defective structure of proteins plays a crucial role. Professor Hartl is the coordinator of the ERC Synergy Grant and contributes his insights about protein folding to the analysis of biochemical and biophysical characteristics of protein aggregates.

Further information: http://www.biochem.mpg.de/hartl

Prof. Dr. Wolfgang Baumeister has been director at the MPI of Biochemistry since 1988, where his department studies large protein complexes that cannot be visualized with conventional methods. For this challenging task he developed the method of cryo-electron tomography, which is now used for the study of large protein aggregates in neurodegenerative diseases. Here the samples are first shock-frozen in liquid nitrogen. Then the scientists take images of the sample from different angles, which they subsequently put together in a three-dimensional image.

Further information: http://www.biochem.mpg.de/baumeister

Prof. Dr. Rüdiger Klein has been director at the MPI of Neurobiology since 2001, where his department studies the role of receptors on the cell surface and their binding partners in the network of nerve cells throughout their entire life span. His particular expertise lies in the development and analysis of cell culture and mouse models of human diseases. Using these models the scientists can explore how the protein aggregates arise and what effects they have.
Further information: http://www.neuro.mpg.de/klein

Prof. Dr. Matthias Mann has been director at the MPI of Biochemistry since 2005. His department is the world leader in the analysis of the proteome, the entirety of all proteins in an organism. Using mass spectrometry, it will be possible to identify proteins in the cell culture and mouse models which cause toxicity in neurodegenerative diseases.

Further information: http://www.biochem.mpg.de/mann

Contact
Dr. Anne Katrin Werenskiold
EU Office
Max Planck Institute of Biochemistry
Phone +49 (0)89 – 8578 2601
e-mail: kwerensk@biochem.mpg.de

Anja Konschak
Press and Public Relations
Max Planck Institute of Biochemistry
Phone +49 (0)89 – 8578 2824
e-mail: konschak@biochem.mpg.de
http://www.biochem.mpg.de
Dr. Stefanie Merker
Press and Public Relations
Max Planck Institute of Neurobiology
Phone +49 (0)89 – 8578 3514
e-mail: merker@neuro.mpg.de
http://www.neuro.mpg.de
Weitere Informationen:

http://www.biochem.mpg.de/hartl
- Website of the Research Department Cellular Biochemistry (F.-Ulrich Hartl)

http://www.biochem.mpg.de/baumeister
- Website of the Research Department Molecular Structural Biology (Wolfgang Baumeister)

http://www.neuro.mpg.de/klein
- Website of Research Department Molecules - Signaling - Development (Rüdiger Klein)

http://www.biochem.mpg.de/mann
- Website of the Research Department "Proteomics and Signal Transduction" (Matthias Mann)

Anja Konschak | Max-Planck-Institut
Weitere Informationen:
http://www.neuro.mpg.de
http://www.biochem.mpg.de

Weitere Nachrichten aus der Kategorie Förderungen Preise:

nachricht 31,5 Millionen Euro für Forschungsinstitute der Innovationsallianz Baden-Württemberg (InnBW)
20.04.2018 | Ministerium für Wirtschaft, Arbeit und Wohnungsbau Baden-Württemberg

nachricht Der Herr der Magnetfelder: EU verleiht HZDR-Forscher begehrte Forschungsförderung in Millionenhöhe
12.04.2018 | Helmholtz-Zentrum Dresden-Rossendorf

Alle Nachrichten aus der Kategorie: Förderungen Preise >>>

Die aktuellsten Pressemeldungen zum Suchbegriff Innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Software mit Grips

Ein computergestütztes Netzwerk zeigt, wie die Ionenkanäle in der Membran von Nervenzellen so verschiedenartige Fähigkeiten wie Kurzzeitgedächtnis und Hirnwellen steuern können

Nervenzellen, die auch dann aktiv sind, wenn der auslösende Reiz verstummt ist, sind die Grundlage für ein Kurzzeitgedächtnis. Durch rhythmisch aktive...

Im Focus: Der komplette Zellatlas und Stammbaum eines unsterblichen Plattwurms

Von einer einzigen Stammzelle zur Vielzahl hochdifferenzierter Körperzellen: Den vollständigen Stammbaum eines ausgewachsenen Organismus haben Wissenschaftlerinnen und Wissenschaftler aus Berlin und München in „Science“ publiziert. Entscheidend war der kombinierte Einsatz von RNA- und computerbasierten Technologien.

Wie werden aus einheitlichen Stammzellen komplexe Körperzellen mit sehr unterschiedlichen Funktionen? Die Differenzierung von Stammzellen in verschiedenste...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Verbesserte Stabilität von Kunststoff-Leuchtdioden

Polymer-Leuchtdioden (PLEDs) sind attraktiv für den Einsatz in großflächigen Displays und Lichtpanelen, aber ihre begrenzte Stabilität verhindert die Kommerzialisierung. Wissenschaftler aus dem Max-Planck-Institut für Polymerforschung (MPIP) in Mainz haben jetzt die Ursachen der Instabilität aufgedeckt.

Bildschirme und Smartphones, die gerollt und hochgeklappt werden können, sind Anwendungen, die in Zukunft durch die Entwicklung von polymerbasierten...

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

VideoLinks
Industrie & Wirtschaft
Veranstaltungen

Internationale Konferenz zur Digitalisierung

19.04.2018 | Veranstaltungen

124. Internistenkongress in Mannheim: Internisten rücken Altersmedizin in den Fokus

19.04.2018 | Veranstaltungen

DFG unterstützt Kongresse und Tagungen - Juni 2018

17.04.2018 | Veranstaltungen

VideoLinks
Wissenschaft & Forschung
Weitere VideoLinks im Überblick >>>
 
Aktuelle Beiträge

Grösster Elektrolaster der Welt nimmt Arbeit auf

20.04.2018 | Interdisziplinäre Forschung

Bilder magnetischer Strukturen auf der Nano-Skala

20.04.2018 | Physik Astronomie

Kieler Forschende entschlüsseln neuen Baustein in der Entwicklung des globalen Klimas

20.04.2018 | Geowissenschaften

Weitere B2B-VideoLinks
IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics