Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Better understanding of cell renewal and cellular quality control

09.12.2015

The German Research Foundation (Deutsche Forschungsgemeinschaft/DFG) has approved 11 million Euro for the next four years for establishing a CRC on selective autophagy under the lead of Goethe University.

The German Research Foundation (Deutsche Forschungsgemeinschaft/DFG) has approved 11 million Euro for the next four years for establishing a CRC on selective autophagy under the lead of Goethe University. Autophagy literally means "self-eating" and refers to a sophisticated system in which cellular waste is specifically detected and removed.

It contributes to regular cell renewal, secures quality control and protects against diseases. Defects in this pathway can promote cancer development and neurodegenerative diseases like Parkinson, and contribute to infectious diseases and inflammatory reactions. The objective of the CRC is a better understanding of autophagy at the molecular and cellular level. In future, the researchers hope to be able to specifically target autophagy for improving the therapy of diverse diseases.

Professor Birgitta Wolff, President of the University, congratulated the researchers: “Well done to Ivan Dikic and his team for achieving this important milestone. The research planned within the CRC forms a promising basis for the development of new and more effective therapies. We are particularly pleased that we will be joining forces with Mainz University, the Institute of Molecular Biology in Mainz and the Georg-Speyer-Haus in the CRC – a further sign of the vitality of our regional partnerships.”

Autophagy is conserved from simple organisms such as yeast up to complex ones like humans. Typical targets for autophagy are harmful or superfluous proteins - it degrades for example aggregated proteins, which can otherwise lead to severe damage and cell death, as observed in numerous neurodegenerative diseases. Even entire cell organelles and invading pathogens such as bacteria or viruses can be eliminated via this pathway. The building blocks generated through this degradation process are recycled, which is why autophagy also functions as a survival strategy in times of low energy supply.

Autophagy is a highly complex and precisely regulated process which requires a concerted action by numerous players: The target substrate needs to be specifically recognized and surrounded by membranes to form what is known as the autophagosome. Autophagosomes fuse with lysosomes, which are cell organelles filled with digestive enzymes, finally enabling the breakdown of all cargo into the individual building blocks.

“The enormous significance of autophagy for the pathophysiology of diseases has only been recognized in the past decade. As a result, research activity in this field has increased rapidly”, explains Professor Ivan Dikic, CRC Speaker and Director of the Institute of Biochemistry II at Goethe University. “By strategic recruitments over the past five years, we have succeeded in developing Frankfurt into a centre for autophagy research. Now we are in a position to address many of the unanswered questions: What triggers autophagy? How does the cell select targets for autophagy? How does this pathway crosstalk to other cellular mechanisms and how is it involved in the pathogenesis of human diseases?”

Meanwhile it is known that the role of autophagy strongly depends on the cellular context: In healthy tissues, it prevents the emergence of cancer cells. At the same time, however, cancer cells capitalize on autophagy to overcome bottlenecks in nutrient supply, which occur as a result of rapid tumour growth. The researchers are now analysing this complex interaction. So far, little is known about the interplay of autophagy with other mechanisms, such as cellular trafficking (endocytosis), programmed cell death (apoptosis) and the ubiquitination system, which marks proteins for degradation in the proteasome.

Within the newly established CRC, researchers will study autophagy at the level of molecules, cells and model organisms. It is the first large-scale collaborative project in this field in Germany and allows scientists in Frankfurt and Mainz to position themselves in an internationally highly competitive field. A broad line-up of disciplines is needed to tackle the open questions, and therefore, within the CRC, structural biologists have teamed up with biochemists, cell biologists and clinicians. New insight into the molecular mechanisms underlying autophagy will be directly transferred to model systems for human diseases.

At Goethe University, the three faculties of Biological Sciences, Biochemistry, Chemistry and Pharmacy, and Medicine, and the cross-disciplinary Buchmann Institute for Molecular Life Sciences (BMLS) are participating in the CRC. Partners outside the University are the Institute for Pathobiochemistry at the University Medical Center of Johannes Gutenberg University Mainz (Prof. Dr. Christian Behl is Vice Speaker of the CRC), the Georg-Speyer-Haus in Frankfurt and the Institute of Molecular Biology gGmbH in Mainz.

Further information: Prof. Ivan Dikic, Institute of Biochemistry II, University Hospital Frankfurt, Tel.: (069) 6301-5652, Ivan.Dikic@biochem2.de.

Goethe University is a research-oriented university in the European financial centre Frankfurt founded in 1914 with purely private funds by liberally-oriented Frankfurt citizens. It is dedicated to research and education under the motto "Science for Society" and to this day continues to function as a "citizens’ university". Many of the early benefactors were Jewish. Over the past 100 years, Goethe University has done pioneering work in the social and sociological sciences, chemistry, quantum physics, brain research and labour law. It gained a unique level of autonomy on 1 January 2008 by returning to its historic roots as a privately funded university. Today, it is among the top ten in external funding and among the top three largest universities in Germany, with three clusters of excellence in medicine, life sciences and the humanities.

Publisher: The President of Goethe University
Editor: Dr. Anke Sauter, Science Editor, International Communication, Tel: +49(0)69 798-12477, Fax +49(0)69 798-761 12531, sauter@pvw.uni-frankfurt.de
Internet: www.uni-frankfurt.de

Dr. Anne Hardy | idw - Informationsdienst Wissenschaft

Weitere Nachrichten aus der Kategorie Förderungen Preise:

nachricht Über 1,6 Millionen Euro für Forschung im Bereich Innovative Materialien und Werkstofftechnologie
17.05.2017 | Hochschule Osnabrück

nachricht MHH-Forscher beleben Narbengewebe in der Leber wieder
16.05.2017 | Medizinische Hochschule Hannover

Alle Nachrichten aus der Kategorie: Förderungen Preise >>>

Die aktuellsten Pressemeldungen zum Suchbegriff Innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Hauchdünne magnetische Materialien für zukünftige Quantentechnologien entwickelt

Zweidimensionale magnetische Strukturen gelten als vielversprechendes Material für neuartige Datenspeicher, da sich die magnetischen Eigenschaften einzelner Molekülen untersuchen und verändern lassen. Forscher haben nun erstmals einen hauchdünnen Ferrimagneten hergestellt, bei dem sich Moleküle mit verschiedenen magnetischen Zentren auf einer Goldfläche selbst zu einem Schachbrettmuster anordnen. Dies berichten Wissenschaftler des Swiss Nanoscience Institutes der Universität Basel und des Paul Scherrer Institutes in der Wissenschaftszeitschrift «Nature Communications».

Ferrimagneten besitzen zwei magnetische Zentren, deren Magnetismus verschieden stark ist und in entgegengesetzte Richtungen zeigt. Zweidimensionale, quasi...

Im Focus: Neuer Ionisationsweg in molekularem Wasserstoff identifiziert

„Wackelndes“ Molekül schüttelt Elektron ab

Wie reagiert molekularer Wasserstoff auf Beschuss mit intensiven ultrakurzen Laserpulsen? Forscher am Heidelberger MPI für Kernphysik haben neben bekannten...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: XENON1T: Das empfindlichste „Auge“ für Dunkle Materie

Gemeinsame Meldung des MPI für Kernphysik Heidelberg, der Albert-Ludwigs-Universität Freiburg, der Johannes Gutenberg-Universität Mainz und der Westfälischen Wilhelms-Universität Münster

„Das weltbeste Resultat zu Dunkler Materie – und wir stehen erst am Anfang!“ So freuen sich Wissenschaftler der XENON-Kollaboration über die ersten Ergebnisse...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

14. Dortmunder MST-Konferenz zeigt individualisierte Gesundheitslösungen mit Mikro- und Nanotechnik

22.05.2017 | Veranstaltungen

Branchentreff für IT-Entscheider - Rittal Praxistage IT in Stuttgart und München

22.05.2017 | Veranstaltungen

Flugzeugreifen – Ähnlich wie PKW-/LKW-Reifen oder ganz verschieden?

22.05.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Myrte schaltet „Anstandsdame“ in Krebszellen aus

22.05.2017 | Biowissenschaften Chemie

Hauchdünne magnetische Materialien für zukünftige Quantentechnologien entwickelt

22.05.2017 | Physik Astronomie

Wie sich das Wasser in der Umgebung von gelösten Molekülen verhält

22.05.2017 | Biowissenschaften Chemie