Forum für Wissenschaft, Industrie und Wirtschaft
Hauptsponsoren:     Siemens  n-tv 
Datenbankrecherche:

Fachgebiet (optional):

 

Home Fachgebiete Biowissenschaften Chemie Nachricht

Identified: DNA that controls the malaria parasite’s disguise mechanism

nächste Meldung
04.01.2006

Anzeige


Professor Alan Cowman, Dr Brendan Crabb and their research teams at WEHI have identified how the most lethal malaria parasite, Plasmodium falciparum, is able to disguise itself from the human immune system.

This discovery builds on the work published in the 9 April 2005 issue of the journal Cell, in which Professor Cowman and Dr Crabb reported that to avoid detection and destruction, the parasite controls expression of 60 key virulence genes, effectively disguising itself from the human host’s immune system. The new discovery identifies the DNA sequence that is needed to switch these genes on and off.


With this greater understanding of the parasite’s disguise-switching mechanism, scientists will now attempt to identify the activating proteins that enable the parasite’s 60 disguises to be switched.

Further along the way, research will concentrate on the design of a drug candidate molecule that will, in effect, freeze the parasite’s capability to change its disguise.

With the parasite thereby converted into a stable and unchanging target, the immune system of the human host should be able to raise an effective immune response against the recognised invader. This should lead to a steep reduction in the severity of the debilitating symptoms that usually accompany malarial infection.

Other members of the discovery team are Till Voss, Julie Healer, Allison Marty, Jennifer Thompson and Michael Duffy.

Brad Allen | Quelle: EurekAlert!
Weitere Informationen: www.researchaustralia.com.au/

nächste Meldung

Weitere Nachrichten aus der Kategorie Biowissenschaften Chemie:

nachricht Feedback loop explains inflammatory effect on intestinal lining
19.03.2010 | Emory University

nachricht Stem cells used to model infant birth defect
19.03.2010 | Children's Hospital Boston

Alle Nachrichten aus der Kategorie Biowissenschaften Chemie >>>

Anzeige

B2B Suche

Produkt / Dienstleistung
Firma / Organisation

Anzeige

Aktuell

Laserdrucker-Emissionen schädigen Lungenzellen

19.03.2010 | Studien Analysen

Rückenschmerzen: Was kostet Lebensqualität?

19.03.2010 | Studien Analysen

The Institute for Ocean Conservation Science applauds IUCN's reclassifcation of beluga sturgeon

19.03.2010 | Ökologie Umwelt- Naturschutz

Innovations Report TV
Reportagen, Interviews und
Video-Highlights auf:

www.innovations-report.tv

... in Kooperation mit
Science-TV & Inventions-TV
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>

Veranstaltungen

China-Woche 2010

19.03.2010 | Veranstaltungsnachrichten

Baufinanzierer setzen auf einen starken Vertrieb

19.03.2010 | Veranstaltungsnachrichten

Heidelberger Innovationsforum: Cleantech & Green IT

19.03.2010 | Veranstaltungsnachrichten

Live-Mitschnitte, Interviews und Hintergründe von den Meinungs-
führern aus Politik und Wirtschaft jetzt auf www.euroforum.tv

FindAndHelp