Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Vitamin D prevents clogged arteries in diabetics

14.11.2012
People with diabetes often develop clogged arteries that cause heart disease, and new research at Washington University School of Medicine in St. Louis suggests that low vitamin D levels are to blame.

In a study published Nov. 9 in the Journal of Biological Chemistry, the researchers report that blood vessels are less like to clog in people with diabetes who get adequate vitamin D. But in patients with insufficient vitamin D, immune cells bind to blood vessels near the heart, then trap cholesterol to block those blood vessels.


Bernal-Mizrachi lab

Low levels of vitamin D in people with diabetes appear to encourage cholesterol to build up in arteries, eventually blocking the flow of blood. In mice, immune cells adhering to the wall of a major blood vessel near the heart are loaded with cholesterol (shown in red).

“About 26 million Americans now have type 2 diabetes,” says principal investigator Carlos Bernal-Mizrachi, MD. “And as obesity rates rise, we expect even more people will develop diabetes. Those patients are more likely to experience heart problems due to an increase in vascular inflammation, so we have been investigating why this occurs.”

In earlier research, Bernal-Mizrachi, an assistant professor of medicine and of cell biology and physiology, and his colleagues found that vitamin D appears to play a key role in heart disease. This new study takes their work a step further, suggesting that when vitamin D levels are low, a particular class of white blood cell is more likely to adhere to cells in the walls of blood vessels.

Vitamin D conspires with immune cells called macrophages either to keep arteries clear or to clog them. The macrophages begin their existence as white blood cells called monocytes that circulate in the bloodstream. But when monocytes encounter inflammation, they are transformed into macrophages, which no longer circulate.

In the new study, researchers looked at vitamin D levels in 43 people with type 2 diabetes and in 25 others who were similar in age, sex and body weight but didn’t have diabetes.

They found that in diabetes patients with low vitamin D — less than 30 nanograms per milliliter of blood — the macrophage cells were more likely to adhere to the walls of blood vessels, which triggers cells to get loaded with cholesterol, eventually causing the vessels to stiffen and block blood flow.

“We took everything into account,” says first author Amy E. Riek, MD, instructor in medicine. “We looked at blood pressure, cholesterol, diabetes control, body weight and race. But only vitamin D levels correlated to whether these cells stuck to the blood vessel wall.”

Riek and Bernal-Mizrachi say what’s not yet clear is whether giving vitamin D to people with diabetes will reverse their risk of developing clogged arteries, a condition called atherosclerosis. They now are treating mice with vitamin D to see whether it can prevent monocytes from adhering to the walls of blood vessels near the heart, and they also are conducting two clinical trials in patients.

In one of those studies, the researchers are giving vitamin D to people with diabetes and hypertension to see whether the treatment may lower blood pressure. In the second study, African Americans with type 2 diabetes are getting vitamin D along with their other daily medications, and the research team is evaluating whether vitamin D supplements can slow or reverse the progression of heart disease.

Sometime in the next several months, the scientists hope to determine whether vitamin D treatment can reverse some of the risk factors associated with cardiovascular disease.

“In the future, we hope to generate medications, potentially even vitamin D itself, that help prevent the deposit of cholesterol in the blood vessels,” Bernal-Mizrachi explains. “Previous studies have linked vitamin D deficiency in these patients to increases in cardiovascular disease and in mortality. Other work has suggested that vitamin D may improve insulin release from the pancreas and insulin sensitivity. Our ultimate goal is to intervene in people with diabetes and to see whether vitamin D might decrease inflammation, reduce blood pressure and lessen the likelihood that they will develop atherosclerosis or other vascular complications.”

For more information on the current clinical studies involving vitamin D in people with diabetes, call study coordinator Robin Bruchas at (314) 362-0934.

Riek AE, Sprague JE, Timpson A, de las Fuentes L, Bernal-Mizrachi L, Schechtman KB, Bernal-Mizrachi C. Vitamin D suppression of endoplasmic reticulum stress promotes an anti-atherogenic monocyte/macrophage phenotype in type 2 diabetic patients. Journal of Biological Chemistry vol. 287 (46), pp. 38482-38494. Nov. 9, 2012

http://www.jbc.org/cgi/doi/10.1074/jbc.M112.386912

Funding for this research comes from the National Heart, Lung and Blood Institute (NHLBI), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Center for Research Resources (NCRR), National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research of the National Institutes of Health (NIH). Support also comes from the American Diabetes Association, the Endocrine Society, the Endocrine Fellows Foundation and the Ruth L. Kirchstein National Research Service Award 2. NIH grant numbers are RO1 HO094818-0, P30DK079333, T32 HD043010, and UL1TRR000448/Sub-Award KL2TR000450.

Washington University School of Medicine’s 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children’s hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children’s hospitals, the School of Medicine is linked to BJC HealthCare.

Jim Dryden | EurekAlert!
Further information:
http://www.wustl.edu

More articles from Life Sciences:

nachricht Navigational view of the brain thanks to powerful X-rays
18.10.2017 | Georgia Institute of Technology

nachricht Separating methane and CO2 will become more efficient
18.10.2017 | KU Leuven

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Schnelle individualisierte Therapiewahl durch Sortierung von Biomolekülen und Zellen mit Licht

Im Blut zirkulierende Biomoleküle und Zellen sind Träger diagnostischer Information, deren Analyse hochwirksame, individuelle Therapien ermöglichen. Um diese Information zu erschließen, haben Wissenschaftler des Fraunhofer-Instituts für Lasertechnik ILT ein Mikrochip-basiertes Diagnosegerät entwickelt: Der »AnaLighter« analysiert und sortiert klinisch relevante Biomoleküle und Zellen in einer Blutprobe mit Licht. Dadurch können Frühdiagnosen beispielsweise von Tumor- sowie Herz-Kreislauf-Erkrankungen gestellt und patientenindividuelle Therapien eingeleitet werden. Experten des Fraunhofer ILT stellen diese Technologie vom 13.–16. November auf der COMPAMED 2017 in Düsseldorf vor.

Der »AnaLighter« ist ein kompaktes Diagnosegerät zum Sortieren von Zellen und Biomolekülen. Sein technologischer Kern basiert auf einem optisch schaltbaren...

Im Focus: Neue Möglichkeiten für die Immuntherapie beim Lungenkrebs entdeckt

Eine gemeinsame Studie der Universität Bern und des Inselspitals Bern zeigt, dass spezielle Bindegewebszellen, die in normalen Blutgefässen die Wände abdichten, bei Lungenkrebs nicht mehr richtig funktionieren. Zusätzlich unterdrücken sie die immunologische Bekämpfung des Tumors. Die Resultate legen nahe, dass diese Zellen ein neues Ziel für die Immuntherapie gegen Lungenkarzinome sein könnten.

Lungenkarzinome sind die häufigste Krebsform weltweit. Jährlich werden 1.8 Millionen Neudiagnosen gestellt; und 2016 starben 1.6 Millionen Menschen an der...

Im Focus: Sicheres Bezahlen ohne Datenspur

Ob als Smartphone-App für die Fahrkarte im Nahverkehr, als Geldwertkarten für das Schwimmbad oder in Form einer Bonuskarte für den Supermarkt: Für viele gehören „elektronische Geldbörsen“ längst zum Alltag. Doch vielen Kunden ist nicht klar, dass sie mit der Nutzung dieser Angebote weitestgehend auf ihre Privatsphäre verzichten. Am Karlsruher Institut für Technologie (KIT) entsteht ein sicheres und anonymes System, das gleichzeitig Alltagstauglichkeit verspricht. Es wird nun auf der Konferenz ACM CCS 2017 in den USA vorgestellt.

Es ist vor allem das fehlende Problembewusstsein, das den Informatiker Andy Rupp von der Arbeitsgruppe „Kryptographie und Sicherheit“ am KIT immer wieder...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Mobilität 4.0: Konferenz an der Jacobs University

18.10.2017 | Veranstaltungen

Smart MES 2017: die Fertigung der Zukunft

18.10.2017 | Veranstaltungen

DFG unterstützt Kongresse und Tagungen - Dezember 2017

17.10.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Schnelle individualisierte Therapiewahl durch Sortierung von Biomolekülen und Zellen mit Licht

18.10.2017 | Biowissenschaften Chemie

Biokunststoffe könnten auch in Traktoren die Richtung angeben

18.10.2017 | Messenachrichten

»ILIGHTS«-Studie gestartet: Licht soll Wohlbefinden von Schichtarbeitern verbessern

18.10.2017 | Energie und Elektrotechnik