John C. Morris, MD, and his colleagues report their findings in the Nov. 13, 2012, issue of PLOS One, a peer-reviewed online publication that features original research from all disciplines within science and medicine.
Stem cells are unique cells that can divide and differentiate into specialized cells types—for example cardiac muscle or liver tissue. These cells also have the ability to self-renew and produce more stem cells.
"Increasing evidence supports the idea that cancerous tumors have a population of stem cells, also called cancer-initiating cells, that continually regenerate and fuel cancer growth," explains Morris, senior author of the study and professor at the UC College of Medicine. "These cancer stem cells may also have the highest potential to spread to other organs."
Current models used to study cancer stem cells provide limited information on the interaction between cancer stem cells with the immune system, making the study of new therapies that utilize the body's immune system to fight off cancer virtually impossible.
In this study, the UC team set out to find a viable, consistent way to isolate lung cancer stem cells that could be used in a mouse model with full immune system function. The team was able to achieve this using a functional laboratory test known as "tumorsphere" assay.
The test—which shows how cells grow in culture—allowed them to enrich for cancer stem cells.
"Studying these unique cells could greatly improve our understanding of lung cancer's origins and lead to the novel therapeutics targeting these cells and help to more effectively eradicate this disease," adds Morris. "Immunotherapy is the future of cancer treatment. We are hopeful that this new method will accelerate our investigation of immunotherapies to specifically target cancer stem cells."
The team is working to characterize how cancer stem cells escape the body's immune system in order to develop more effective therapies that target stem cells.
"One of the hypotheses behind why cancer therapies fail is that the drug only kills cells deemed to be 'bad' (because of certain molecular characteristics), but leaves behind stem cells to repopulate the tumor," adds Morris. "Stem cells are not frequently dividing, so they are much less sensitive to existing chemotherapies used to eliminate cells deemed abnormal."
UC study collaborators in this UC-funded study include hematology oncology postdoctoral fellow Brian Morrison, PhD, and Jason Steel, PhD, a lung cancer researcher and assistant professor of research at the UC College of Medicine.
The University of Cincinnati Cancer Institute is one of four UC and UC Health collaborative centers of excellence for research, patient care and education. The UC Cancer Institute and Cincinnati Children's Hospital Medical Center Cancer and Blood Diseases Institute together form the Cincinnati Cancer Center, a joint cancer initiative aimed at advancing cancer care faster through innovative research.
Amanda Harper | EurekAlert!
Biomarkers for identifying Tumor Aggressiveness
26.07.2017 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
The dense vessel network regulates formation of thrombocytes in the bone marrow
25.07.2017 | Rudolf-Virchow-Zentrum für Experimentelle Biomedizin der Universität Würzburg
Starke Licht-Materie-Kopplung in diesen halbleitenden Röhrchen könnte zu elektrisch gepumpten Lasern führen
Auch durch Anregung mit Strom ist die Erzeugung von leuchtenden Quasiteilchen aus Licht und Materie in halbleitenden Kohlenstoff-Nanoröhrchen möglich....
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Jenaer Forschern ist es gelungen breitbandiges Laserlicht im mittleren Infrarotbereich mit Hilfe von flüssigkeitsgefüllten optischen Fasern zu erzeugen. Mit den Fasern lieferten sie zudem experimentelle Beweise für eine neue Dynamik von Solitonen – zeitlich und spektral stabile Lichtwellen – die aufgrund der besonderen Eigenschaften des Flüssigkerns entsteht. Die Ergebnisse der Arbeiten publizierte das Jenaer Wissenschaftler-Team vom Leibniz-Instituts für Photonische Technologien (Leibniz-IPHT), dem Fraunhofer-Insitut für Angewandte Optik und Feinmechanik, der Friedrich-Schiller-Universität Jena und des Helmholtz-Insituts im renommierten Fachblatt Nature Communications.
Aus einem ultraschnellen intensiven Laserpuls, den sie in die Faser einkoppeln, erzeugen die Wissenschaftler ein, für das menschliche Auge nicht sichtbares,...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
25.07.2017 | Veranstaltungen
24.07.2017 | Veranstaltungen
24.07.2017 | Veranstaltungen
25.07.2017 | Unternehmensmeldung
25.07.2017 | Seminare Workshops
25.07.2017 | Biowissenschaften Chemie