Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Researchers in Manchester find genetic key to preventing spine tumors

19.02.2013
Genetic medicine experts from Manchester Biomedical Research Centre at Saint Mary's Hospital and The University of Manchester have identified a new gene responsible for causing an inherited form of tumour, known as spinal meningioma.

Professor Richard Marias, Director of the Paterson Institute Meningiomas are the commonest form of tumour affecting the brain and spine. Usually meningiomas can be removed by surgery and do not recur. Occasionally people can develop more than one meningioma or many members of the same family can be affected.

A team led by Dr Miriam Smith, Professor Gareth Evans and Dr Bill Newman worked with families with a history of meningiomas affecting the spinal cord. Using a powerful new genetic sequencing technique called next generation sequencing, they were able to check all the genes of three individuals with multiple spinal meningiomas. This lead to the identification that changes in a gene called SMARCE1 lead to spinal meningiomas in some families.

In December 2012 the government announced a focus on genetic sequencing with an aim of sequencing the genomes (a person's DNA) of 100,000 Britons with cancer and rare diseases in UK centres. The voluntary sequencing of patients will lead to better testing, better drugs and above all better care for patients. Manchester is already using this technology in their well established Genetics department at Saint Mary's and it is enabling doctors to ensure patients have access to the right drugs and personalised care quicker than ever before.

In the past year 10 genes have been discovered using the new next generation sequencing technology in Manchester including genes for developmental problems, deafness, short stature and bladder problems that lead to kidney failure.

"With our new DNA sequencing machines, we have been able to show that changes in the SMARCE1 gene are responsible for multiple spinal meningioma disease," said Dr Smith. "Before our work, doctors did not know that inherited spinal meningiomas have a completely different cause to other tumours affecting the brain and spine.

"The next step is to develop a screening programme to assess the risk of developing spinal tumours for individuals in affected families, and to investigate possible treatments to prevent the spinal tumours from growing."

Professor Richard Marias, Director of Cancer Research UK's Paterson Institute at The University of Manchester, said "This research highlights the complexity of tumour diagnosis. Such detailed molecular characterisation underpins current thoughts about how meningioma and cancer will be managed in the future and is at the heart of the personalised medicine approach."

Just over two people in every 100,000 develop meningiomas in the head and spine, with twice as many women as men diagnosed with the condition.

The team's pioneering work was funded by The Children's Tumor Foundation, a US-based charity supporting neurofibromatosis research, and the Association for International Cancer Research, a global cancer research charity.

Alison Barbuti | EurekAlert!
Further information:
http://www.manchester.ac.uk

More articles from Life Sciences:

nachricht Severity of enzyme deficiency central to favism
26.07.2016 | Universität Zürich

nachricht From vision to hand action
26.07.2016 | Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-assembling nano inks form conductive and transparent grids during imprint

Transparent electronics devices are present in today’s thin film displays, solar cells, and touchscreens. The future will bring flexible versions of such devices. Their production requires printable materials that are transparent and remain highly conductive even when deformed. Researchers at INM – Leibniz Institute for New Materials have combined a new self-assembling nano ink with an imprint process to create flexible conductive grids with a resolution below one micrometer.

To print the grids, an ink of gold nanowires is applied to a substrate. A structured stamp is pressed on the substrate and forces the ink into a pattern. “The...

Im Focus: Neues Forschungsnetzwerk für Mikrobiomforschung

Mikroben und Viren haben weitreichenden Einfluss auf die Gesundheit von Mensch und Tier. Die neu gegründete "Austrian Microbiome Initiative" (AMICI) fördert die nationale Mikrobiomforschung und vernetzt MedizinerInnen und ForscherInnen verschiedenster Fachrichtungen zur Nutzung von Synergien.

Bakterien, Archaeen, Pilze, Viren – Milliarden von Mikroorganismen leben in Symbiose in und auf Menschen und Tieren. Diese mikroskopisch kleinen Lebewesen...

Im Focus: The Glowing Brain

A new Fraunhofer MEVIS method conveys medical interrelationships quickly and intuitively with innovative visualization technology

On the monitor, a brain spins slowly and can be examined from every angle. Suddenly, some sections start glowing, first on the side and then the entire back of...

Im Focus: Superschneller Internetfunk dank Terahertz-Strahlung

Wissenschaftler aus Dresden und Dublin haben einen vielversprechenden technologischen Ansatz gefunden, der Notebooks und anderen mobilen Computern in Zukunft deutlich schnellere Internet-Funkzugänge ermöglichen könnte als bisher. Die Teams am Helmholtz-Zentrum Dresden-Rossendorf (HZDR) und am irischen Trinity College Dublin brachten hauchdünne Schichten aus einer speziellen Verbindung von Mangan und Gallium dazu, sehr effizient Strahlung im sogenannten Terahertz-Frequenzbereich auszusenden. Als Sender in WLAN-Funknetzen eingesetzt, könnten die höheren Frequenzen die Datenraten zukünftiger Kommunikations-Netzwerke spürbar erhöhen.

„Wir halten diesen Ansatz für technologisch sehr interessant“, betont Dr. Michael Gensch, Leiter einer Arbeitsgruppe am HZDR, die sich mit den...

Im Focus: Newly discovered material property may lead to high temp superconductivity

Researchers at the U.S. Department of Energy's (DOE) Ames Laboratory have discovered an unusual property of purple bronze that may point to new ways to achieve high temperature superconductivity.

While studying purple bronze, a molybdenum oxide, researchers discovered an unconventional charge density wave on its surface.

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

8. Forum Energie

26.07.2016 | Veranstaltungen

Kongress für Molekulare Medizin: Krankheiten interdisziplinär verstehen und behandeln

20.07.2016 | Veranstaltungen

Ultraschnelle Kalorimetrie: Gesellschaft für thermische Analyse GEFTA lädt zur Jahrestagung

19.07.2016 | Veranstaltungen

 
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Vernetzt und intuitiv: HEIDENHAIN-Steuerungen in der digitalen Fertigung

26.07.2016 | Messenachrichten

mayr® Antriebstechnik auf der Wind Energy 2016

26.07.2016 | Messenachrichten

Miniaturisiertes Infrarot-Thermometer für Kunststoff-Folien

26.07.2016 | Messenachrichten