Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Researchers in Manchester find genetic key to preventing spine tumors

19.02.2013
Genetic medicine experts from Manchester Biomedical Research Centre at Saint Mary's Hospital and The University of Manchester have identified a new gene responsible for causing an inherited form of tumour, known as spinal meningioma.

Professor Richard Marias, Director of the Paterson Institute Meningiomas are the commonest form of tumour affecting the brain and spine. Usually meningiomas can be removed by surgery and do not recur. Occasionally people can develop more than one meningioma or many members of the same family can be affected.

A team led by Dr Miriam Smith, Professor Gareth Evans and Dr Bill Newman worked with families with a history of meningiomas affecting the spinal cord. Using a powerful new genetic sequencing technique called next generation sequencing, they were able to check all the genes of three individuals with multiple spinal meningiomas. This lead to the identification that changes in a gene called SMARCE1 lead to spinal meningiomas in some families.

In December 2012 the government announced a focus on genetic sequencing with an aim of sequencing the genomes (a person's DNA) of 100,000 Britons with cancer and rare diseases in UK centres. The voluntary sequencing of patients will lead to better testing, better drugs and above all better care for patients. Manchester is already using this technology in their well established Genetics department at Saint Mary's and it is enabling doctors to ensure patients have access to the right drugs and personalised care quicker than ever before.

In the past year 10 genes have been discovered using the new next generation sequencing technology in Manchester including genes for developmental problems, deafness, short stature and bladder problems that lead to kidney failure.

"With our new DNA sequencing machines, we have been able to show that changes in the SMARCE1 gene are responsible for multiple spinal meningioma disease," said Dr Smith. "Before our work, doctors did not know that inherited spinal meningiomas have a completely different cause to other tumours affecting the brain and spine.

"The next step is to develop a screening programme to assess the risk of developing spinal tumours for individuals in affected families, and to investigate possible treatments to prevent the spinal tumours from growing."

Professor Richard Marias, Director of Cancer Research UK's Paterson Institute at The University of Manchester, said "This research highlights the complexity of tumour diagnosis. Such detailed molecular characterisation underpins current thoughts about how meningioma and cancer will be managed in the future and is at the heart of the personalised medicine approach."

Just over two people in every 100,000 develop meningiomas in the head and spine, with twice as many women as men diagnosed with the condition.

The team's pioneering work was funded by The Children's Tumor Foundation, a US-based charity supporting neurofibromatosis research, and the Association for International Cancer Research, a global cancer research charity.

Alison Barbuti | EurekAlert!
Further information:
http://www.manchester.ac.uk

More articles from Life Sciences:

nachricht Complete skin regeneration system of fish unraveled
24.04.2018 | Tokyo Institute of Technology

nachricht Scientists generate an atlas of the human genome using stem cells
24.04.2018 | The Hebrew University of Jerusalem

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: BAM@Hannover Messe: Innovatives 3D-Druckverfahren für die Raumfahrt

Auf der Hannover Messe 2018 präsentiert die Bundesanstalt für Materialforschung und -prüfung (BAM), wie Astronauten in Zukunft Werkzeug oder Ersatzteile per 3D-Druck in der Schwerelosigkeit selbst herstellen können. So können Gewicht und damit auch Transportkosten für Weltraummissionen deutlich reduziert werden. Besucherinnen und Besucher können das innovative additive Fertigungsverfahren auf der Messe live erleben.

Pulverbasierte additive Fertigung unter Schwerelosigkeit heißt das Projekt, bei dem ein Bauteil durch Aufbringen von Pulverschichten und selektivem...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: IWS-Ingenieure formen moderne Alu-Bauteile für zukünftige Flugzeuge

Mit Unterdruck zum Leichtbau-Flugzeug

Ingenieure des Fraunhofer-Instituts für Werkstoff- und Strahltechnik (IWS) in Dresden haben in Kooperation mit Industriepartnern ein innovatives Verfahren...

Im Focus: Moleküle brillant beleuchtet

Physiker des Labors für Attosekundenphysik, der Ludwig-Maximilians-Universität und des Max-Planck-Instituts für Quantenoptik haben eine leistungsstarke Lichtquelle entwickelt, die ultrakurze Pulse über einen Großteil des mittleren Infrarot-Wellenlängenbereichs generiert. Die Wissenschaftler versprechen sich von dieser Technologie eine Vielzahl von Anwendungen, unter anderem im Bereich der Krebsfrüherkennung.

Moleküle sind die Grundelemente des Lebens. Auch wir Menschen bestehen aus ihnen. Sie steuern unseren Biorhythmus, zeigen aber auch an, wenn dieser erkrankt...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

VideoLinks
Industrie & Wirtschaft
Veranstaltungen

infernum-Tag 2018: Digitalisierung und Nachhaltigkeit

24.04.2018 | Veranstaltungen

Fraunhofer eröffnet Community zur Entwicklung von Anwendungen und Technologien für die Industrie 4.0

23.04.2018 | Veranstaltungen

Mars Sample Return – Wann kommen die ersten Gesteinsproben vom Roten Planeten?

23.04.2018 | Veranstaltungen

VideoLinks
Wissenschaft & Forschung
Weitere VideoLinks im Überblick >>>
 
Aktuelle Beiträge

Demographie beeinflusst Brutfürsorge bei Regenpfeifern

25.04.2018 | Biowissenschaften Chemie

Die Zukunft des Fliegens auf dem Prüfstand

25.04.2018 | Maschinenbau

Rittal digitalisiert Fertigung - Produktion weltweit nach Industrie 4.0

25.04.2018 | HANNOVER MESSE

Weitere B2B-VideoLinks
IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics