Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Researchers identify proteins that indicate which kidney tumors are most likely to spread

06.12.2012
Discovery will help physicians recognize which tumours are going to behave more aggressively
Researchers at St. Michael's hospital have identified 29 proteins that are likely to be involved in the spread of kidney cancer. The discovery will help physicians recognize which tumours are going to behave more aggressively and provide those patients with more intensive treatment and closer followup.

"Metastatic renal cell carcinoma is one of the most treatment-resistant malignancies and patients have dismal prognosis," said Dr. George M Yousef, a laboratory pathologist. "Identification of markers that can predict the potential of metastases will have a great impact on improvement patient outcomes.

Dr. Yousef's research appears online in the journal Molecular & Cellular Proteomics.

Kidney cancer in general is very aggressive and has a high chance of metastasis, or spreading to other organs. The five-year survival rate for metastasized kidney cancer is less than 10 per cent. Although imaging technology has led to increased detection of kidney tumours, 25 to 30 per cent have already spread by the time they are found.

Using a mass spectrometer, Dr. Yousef identified 29 proteins that change when cancer cells spread from the original site of the kidney tumour. All 29 proteins have been previously been linked to other malignancies.

Dr. Yousef said if physicians can determine which kidney tumours have those proteins, and are likely to spread, they can monitor and treat those patients more aggressively. Patients who don't have those proteins and biomarkers might not have to undergo costly and intensive treatment or surgery.

The next steps would be to find ways to stop the proteins from turning on and triggering the metastasis.

This study was supported by grants from the Canadian Cancer Society, the Ontario Ministry of Research and Innovation, the Kidney Foundation of Canada and the Cancer Research Society.

About St. Michael's Hospital
St. Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, and care of the homeless are among the Hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Center, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.

For more information or to interview Dr.Yousef, please contact:

Leslie Shepherd
Manager, Media Strategy
St. Michael's Hospital
Phone: 416-864-6094 or 647-300-1753
shepherdl@smh.ca
Inspired Care. Inspiring Science.

Leslie Shepherd | EurekAlert!
Further information:
http://www.smh.ca

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Orientierungslauf im Mikrokosmos

Physiker der Universität Würzburg können auf Knopfdruck einzelne Lichtteilchen erzeugen, die einander ähneln wie ein Ei dem anderen. Zwei neue Studien zeigen nun, welches Potenzial diese Methode hat.

Der Quantencomputer beflügelt seit Jahrzehnten die Phantasie der Wissenschaftler: Er beruht auf grundlegend anderen Phänomenen als ein herkömmlicher Rechner....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Tumult im trägen Elektronen-Dasein

Ein internationales Team von Physikern hat erstmals das Streuverhalten von Elektronen in einem nichtleitenden Material direkt beobachtet. Ihre Erkenntnisse könnten der Strahlungsmedizin zu Gute kommen.

Elektronen in nichtleitenden Materialien könnte man Trägheit nachsagen. In der Regel bleiben sie an ihren Plätzen, tief im Inneren eines solchen Atomverbunds....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Hauchdünne magnetische Materialien für zukünftige Quantentechnologien entwickelt

Zweidimensionale magnetische Strukturen gelten als vielversprechendes Material für neuartige Datenspeicher, da sich die magnetischen Eigenschaften einzelner Molekülen untersuchen und verändern lassen. Forscher haben nun erstmals einen hauchdünnen Ferrimagneten hergestellt, bei dem sich Moleküle mit verschiedenen magnetischen Zentren auf einer Goldfläche selbst zu einem Schachbrettmuster anordnen. Dies berichten Wissenschaftler des Swiss Nanoscience Institutes der Universität Basel und des Paul Scherrer Institutes in der Wissenschaftszeitschrift «Nature Communications».

Ferrimagneten besitzen zwei magnetische Zentren, deren Magnetismus verschieden stark ist und in entgegengesetzte Richtungen zeigt. Zweidimensionale, quasi...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Meeresschutz im Fokus: Das IASS auf der UN-Ozean-Konferenz in New York vom 5.-9. Juni

24.05.2017 | Veranstaltungen

Diabetes Kongress in Hamburg beginnt heute: Rund 6000 Teilnehmer werden erwartet

24.05.2017 | Veranstaltungen

Wissensbuffet: „All you can eat – and learn”

24.05.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Hochspannung für den Teilchenbeschleuniger der Zukunft

24.05.2017 | Physik Astronomie

3D-Graphen: Experiment an BESSY II zeigt, dass optische Eigenschaften einstellbar sind

24.05.2017 | Physik Astronomie

Optisches Messverfahren für Zellanalysen in Echtzeit - Ulmer Physiker auf der Messe "Sensor+Test"

24.05.2017 | Messenachrichten