Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Neuronal activity induces tau release from healthy neurons

15.02.2013
Researchers from King’s College London have discovered that neuronal activity can stimulate tau release from healthy neurons in the absence of cell death.

The results published by Diane Hanger and her colleagues in EMBO reports show that treatment of neurons with known biological signaling molecules increases the release of tau into the culture medium. The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity.

Tau proteins stabilize microtubules, the long threads of polymers that help to maintain the structure of the cell. However, in Alzheimer’s disease or certain types of dementia, tau accumulates in neurons or glial cells, where it contributes to neurodegeneration.

In addition to intracellular aggregation, recent experiments have shown that tau is released from neuronal cells and taken up by neighboring cells, which allows the spread of aggregated tau across the brain. This release could occur passively from dying neuronal cells, though some evidence suggests it might take place before neuronal cell death and neurodegeneration. The new findings indicate that tau release is an active process in healthy neurons and this could be altered in diseased brains.

“Our findings suggest that altered tau release is likely to occur in response to changes in neuronal excitability in the Alzheimer’s brain. Secreted tau could therefore be involved in the propagation of tau pathology in tauopathies, a group of neurodegenerative diseases associated with the accumulation of tau proteins in the brain,” commented Diane Hanger, Reader in the Department of Neuroscience at King’s College London. In these experiments, Amy Pooler, the lead author, revealed that molecules such as potassium chloride, glutamate or an AMPA receptor agonist could release tau from cortical neurons in an active physiological process that is, at least partially, dependent on pre-synaptic vesicle secretion.

The new findings by the scientists indicate that tau has previously unknown roles in biological signaling between cells, in addition to its well-established role in stabilizing microtubules.

“We believe that targeting the release of tau could be explored as a new therapeutic approach for the treatment of Alzheimer’s disease and related tauopathies,” said Hanger. Additional studies are needed in model organisms to test this hypothesis further.

Physiological release of endogenous tau is stimulated by neuronal activity

Amy M Pooler, Emma C Phillips, Dawn HW Lau, Wendy Noble, Diane P Hanger

Read the paper:
http://www.nature.com/embor/journal/vaop/ncurrent/full/embor201315a.html
doi: 10.1038/embor.2013.15
Further information on EMBO reports is available at http://www.nature.com/embor
Media Contacts
Barry Whyte
Head | Public Relations and Communications
barry.whyte@embo.org
Barbara Pauly
Editor
pauly@embo.org
Tel: +49 6221 8891 109
About EMBO
EMBO is an organization of more than 1500 leading researchers that promotes excellence in the life sciences. The major goals of the organization are to sup-port talented researchers at all stages of their careers, stimulate the exchange of scientific information, and help build a European research environment where scientists can achieve their best work.

EMBO helps young scientists to advance their research, promote their interna-tional reputations and ensure their mobility. Courses, workshops, conferences and scientific journals disseminate the latest research and offer training in techniques to maintain high standards of excellence in research practice. EMBO helps to shape science and research policy by seeking input and feedback from our community and by following closely the trends in science in Europe.

Yvonne Kaul | idw
Further information:
http://www.embo.org
http://www.nature.com/embor

More articles from Life Sciences:

nachricht Northwestern scientists develop first liquid nanolaser
27.04.2015 | Northwestern University

nachricht Why do animals fight members of other species?
24.04.2015 | University of California - Los Angeles

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Hummelgenom entschlüsselt

Eine Kollaboration von Forschenden unter ETH-Federführung hat das Genom von zwei kommerziell bedeutenden Hummelarten aufgeklärt. Die Resultate bieten unerwartete Einblicke in Ökologie und Evolution der Hummeln und auch der Honigbiene.

Hummeln gelten als friedfertig und fleissig. Nicht zuletzt seit es weltweit mit der Honigbiene bergab geht, ist der kommerzielle Wert dieser Insekten...

Im Focus: Elektromobilität: Ultraleichtes Kraftpaket für das elektrische Fliegen

Siemens hat einen einzigartigen Elektromotor entwickelt, der hohe Leistung mit einem minimalen Gewicht kombiniert. Durch konsequente Optimierung aller Komponenten stellt der neue Antrieb in seiner Klasse einen Weltrekord beim Leistungsgewicht auf. Dadurch kommt der routinemäßige Einsatz von elektrisch angetriebenen Flugzeugen oder Helikoptern einen großen Schritt näher.

Manchmal lässt sich eine technische Revolution ganz knapp in einer einzigen Zahl zusammenfassen. In diesem Fall lautet sie: fünf Kilowatt pro Kilogramm – das...

Im Focus: Fast and Accurate 3-D Imaging Technique to Track Optically-Trapped Particles

KAIST researchers published an article on the development of a novel technique to precisely track the 3-D positions of optically-trapped particles having complicated geometry in high speed in the April 2015 issue of Optica.

Daejeon, Republic of Korea, April 23, 2015--Optical tweezers have been used as an invaluable tool for exerting micro-scale force on microscopic particles and...

Im Focus: Von Innen nach Außen: Rätsel der galaktischen Scheiben gelöst

Ein Team von Astronomen unter der Leitung von Ivan Minchev, Wissenschaftler am Leibniz-Institut für Astrophysik Potsdam (AIP), hat mithilfe hochmoderner theoretischer Modelle das Rätsel um die Entwicklung der Galaxienscheiben gelöst. Die jetzt veröffentlichte Studie zeigt, dass sich Sternpopulationen gleichen Alters durch Galaxienkollisionen nach außen hin ausweiten. Ähnlich wie die Blüten einer Rose reichern sich diese Populationen schichtweise in der Galaxie an und formen so allmählich die dicke Scheibe.

„Wir können nun zum ersten Mal zeigen, dass dicke Scheiben nicht nur aus alten Sterngenerationen bestehen, sondern – in einem größeren Abstand zum...

Im Focus: NOAA, Tulane identify second possible specimen of 'pocket shark' ever found

Pocket sharks are among the world's rarest finds

A very small and rare species of shark is swimming its way through scientific literature. But don't worry, the chances of this inches-long vertebrate biting...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Evolution von Materialhybridkonzepten

27.04.2015 | Veranstaltungen

Schall und Schwingung

27.04.2015 | Veranstaltungen

Energiemanager diskutieren über Zukunft des kommunalen Energiemanagements

27.04.2015 | Veranstaltungen

 
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Innovatives Hausbaukonzept aus Plastikelementen

27.04.2015 | Architektur Bauwesen

Starke Sache – Neueste Erkenntnisse zur Muskelfunktion

27.04.2015 | Biowissenschaften Chemie

INTERGEO positioniert UAS-Aussteller neu

27.04.2015 | Messenachrichten