Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Possible link between immune system and Alzheimer's

15.11.2012
U of T researchers help discover genetic mutation linked to disease
An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease.

Using data from 25,000 people, researchers from the Faculty of Medicine and University College London's Institute of Neurology discovered that a rare genetic mutation in the TREM2 gene — which helps trigger immune system responses — is also associated with increased risk of Alzheimer's. The discovery supports an emerging theory about the role of the immune system in the disease.

"This discovery provides an increasingly firm link between brain inflammation and increased risk for Alzheimer's," says Dr. Peter St George-Hyslop, director of U of T's Tanz Centre for Research in Neurodegenerative Diseases. "This is an important step towards unraveling the hidden causes of this disease, so that we can develop treatments and interventions to end one of the 21st century's most significant health challenges."

St George-Hyslop, renowned for identifying five genes associated with Alzheimer's disease, says the breakthrough is, "another win for U of T scientists who are building on a worldwide legacy of expertise in neurodegenerative research."

The team began by sequencing the genes of 1,092 people with Alzheimer's and a control group of 1,107 healthy people. The results showed several mutations in the TREM2 gene occurred more frequently in people who had the disease than in those without the disease. One mutation – known as R47H – had a particularly strong association with the disease.

The mutation makes a patient three times more likely to develop the disease, although it affects just 0.3 per cent of the population.

"While the genetic mutation we found is extremely rare, its effect on the immune system is a strong indicator that this system may be a key player in the disease," says Dr. Rita Geurreiro from UCL, the study's lead author.

The study is published now in the New England Journal of Medicine.

Nicole Bodnar | EurekAlert!
Further information:
http://www.utoronto.ca

More articles from Life Sciences:

nachricht Microbial Communities for Health and Environment : Precise Measurements of Microbial Ecosystems
26.11.2014 | Universität Luxemburg - Université du Luxembourg

nachricht How various brain areas interact in decisions
26.11.2014 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Kommunikation zwischen Autos: 1. internationale IEEE-Konferenz vom 3.-5.12. in Paderborn

26.11.2014 | Veranstaltungen

Singles in Shanghai

26.11.2014 | Veranstaltungen

Fachtagung zu nachhaltiger Mobilität in den Städten

26.11.2014 | Veranstaltungen

 
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Kommunikation zwischen Autos: 1. internationale IEEE-Konferenz vom 3.-5.12. in Paderborn

26.11.2014 | Veranstaltungsnachrichten

Lichtausbreitung in Solarzelle sichtbar gemacht

26.11.2014 | Energie und Elektrotechnik

Lizenz an Fortune SG Fund Management Co. für ersten passiven DAX-Indexfonds in China

26.11.2014 | Wirtschaft Finanzen