Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Genome sequencing of Burkitt Lymphoma reveals unique mutation

13.11.2012
In the first broad genetic landscape mapped of a Burkitt lymphoma tumor, scientists at Duke Medicine and their collaborators identified 70 mutations, including several that had not previously been associated with cancer and a new one that was unique to the disease.

Findings from the genetic sequencing of Burkitt lymphoma, an aggressive form of lymphoma, could be used to develop new drugs or aim existing therapies at mutations known to be susceptible. The researchers published their findings online Sunday, Nov. 11, 2012, in the journal Nature Genetics.

"This study lays out the most common genetic alterations in the disease, and allows us to understand the biology of the disease so we can design better therapies," said Sandeep S. Dave, M.D., MBA, MS, associate professor at Duke and senior author of the study.

Dave and colleagues sequenced the first complete Burkitt lymphoma genome, plus the genes from 59 additional Burkitt cases and 94 diffuse large B cell lymphomas, which share many of the same characteristics of Burkitt lymphoma. Similarities between the malignancies can often lead to mistaken diagnoses and failed treatments.

The researchers reported striking differences in the gene mutation patterns of Burkitt lymphomas vs. the diffuse large B cell lymphomas.

"It's important that doctors make the right diagnosis for Burkitt lymphoma, which can be cured with the correct therapies," Dave said. "But if misdiagnosed and given the standard chemotherapy regimes for diffuse large B cell lymphomas, Burkitt lymphoma patients invariably relapse."

The analysis identified 70 genes that were frequently mutated in the Burkitt lymphomas, including a number of genes that were identified in cancer for the first time. One of the newly identified gene mutations, ID3, appeared in 34 percent of the Burkitt cases, but was not evident in any of the diffuse large B cell lymphomas. The mutation has a silencing effect on a gene that suppresses cell growth, enabling cells to multiply.

Dave said this alteration alone may not cause cancer, but when it occurs along with the MYC gene mutations that are common in Burkitt lymphoma and other malignancies, it works like an accelerant to fuel tumor growth. That finding could prove helpful for developing a new drug to function like a normal ID3 gene and suppress cancer cell proliferation in lymphomas as well as numerous other cancers.

"If we can find a way to mimic ID3, restoring the function of the gene to slow the growth of tumors, this could provide a new treatment approach," Dave said. "We have experiments that suggest this is the case, but much more research is needed. This work provides a starting point."

Study co-authors from Dave's laboratory at Duke include first author Cassandra Love, plus Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Adrienne Greenough, Andrea B. Moffitt, Matthew McKinney, Vladimir Grubor; from the Duke Department of Statistics, co-authors include Anjishnu Banerjee and David B. Dunson; and from the Hematologic Malignancies Research Consortium, an international consortium of more than a dozen institutions around the world, co-authors are Rodney Miles, Kristy L. Richards, Cherie H. Dunphy, William W.L. Choi, Gopesh Srivastava, Shawn Levy, Patricia L. Lugar, David Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher R. Flowers, Kikkeri N. Naresh, Andrew M. Evens, Amy Chadburn, Leo I. Gordon, Magdalena B. Czader, Javed I. Gill and Eric D. Hsi.

The study was funded with a donation from Charles and Daneen Stiefel, and grants from the American Cancer Society and the National Institutes of Health (R21CA156168 and R01CA136895).

Sarah Avery | EurekAlert!
Further information:
http://www.duke.edu

More articles from Life Sciences:

nachricht Epilepsy at the Molecular Level
10.02.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht The herbivore dilemma: How corn plants fights off simultaneous attacks
09.02.2016 | Boyce Thompson Institute for Plant Research

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fließphänomene an festen Oberflächen: Grenzflächengeschwindigkeit als wichtige Größe nachgewiesen

Wie man bewirken kann, dass Flüssigkeiten auf festen Oberflächen fast wie ein Schlitten gleiten können, haben jetzt Physiker der Saar-Universität gemeinsam mit Forscherkollegen aus Paris gezeigt: Möglich ist das durch Beschichtungen, die an der Grenzfläche zwischen Flüssigkeit und Oberfläche ein Rutschen der Flüssigkeit provozieren. In der Folge vergrößern sich auch die mittlere Fließgeschwindigkeit und der Durchsatz. Gezeigt wurde dies am Verhalten von Tropfen auf verschieden beschichteten Oberflächen beim Übergang in den Gleichgewichtszustand. Die Ergebnisse könnten für die Optimierung industrieller Prozesse nutzbar sein, beispielsweise zur Verarbeitung von Kunststoffen.

Die Studie wurde in der Fachzeitschrift PNAS (Proceedings of the National Academy of Sciences of the United States of America) veröffentlicht.

Im Focus: Flow phenomena on solid surfaces: Physicists highlight key role played by boundary layer velocity

Physicists from Saarland University and the ESPCI in Paris have shown how liquids on solid surfaces can be made to slide over the surface a bit like a bobsleigh on ice. The key is to apply a coating at the boundary between the liquid and the surface that induces the liquid to slip. This results in an increase in the average flow velocity of the liquid and its throughput. This was demonstrated by studying the behaviour of droplets on surfaces with different coatings as they evolved into the equilibrium state. The results could prove useful in optimizing industrial processes, such as the extrusion of plastics.

The study has been published in the respected academic journal PNAS (Proceedings of the National Academy of Sciences of the United States of America).

Im Focus: Supraleitung: Fußbälle ohne Widerstand

Hinweise auf einen lichtinduzierten verlustfreien Stromtransport in Alkali-Fulleriden helfen bei der Suche nach supraleitenden Materialien für die Praxis.

Supraleiter bleiben einstweilen in Nischenanwendungen verbannt. Da selbst die besten dieser Materialien erst bei minus 70 Grad Celsius ihren elektrischen...

Im Focus: New study: How stable is the West Antarctic Ice Sheet?

Exceeding critical temperature limits in the Southern Ocean may cause the collapse of ice sheets and a sharp rise in sea levels

A future warming of the Southern Ocean caused by rising greenhouse gas concentrations in the atmosphere may severely disrupt the stability of the West...

Im Focus: Superconductivity: footballs with no resistance

Indications of light-induced lossless electricity transmission in fullerenes contribute to the search for superconducting materials for practical applications.

Superconductors have long been confined to niche applications, due to the fact that the highest temperature at which even the best of these materials becomes...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

FZI Open House: IKT-Forschung für die Praxis hautnah erleben

09.02.2016 | Veranstaltungen

KIT 2016: Infektiologen und Tropenmediziner tagen in Würzburg

08.02.2016 | Veranstaltungen

11. European Bioplastics Konferenz 2016

08.02.2016 | Veranstaltungen

 
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Supraleitung: Fußbälle ohne Widerstand

09.02.2016 | Physik Astronomie

Beinahe Unmögliches aus dem 3D-Drucker

09.02.2016 | Informationstechnologie

Das große Strömen zum Licht

09.02.2016 | Biowissenschaften Chemie