The test, reported in the online medical journal PLoS One, is based on the finding that different subtypes of the FMR1 gene (also known as the fragile X mental retardation gene) in potential mothers are associated with significantly different chances of conceiving with IVF.
“This is the first evidence that a specific gene appears to be directly associated with IVF outcomes,” said David Barad, M.D., associate clinical professor of epidemiology & population health and of obstetrics & gynecology and women’s health at Einstein and one of the study’s senior authors. Dr. Barad is also director of assisted reproduction at the Center for Human Reproduction (CHR) in New York City.
“Our research also suggests the FMR1 gene, some forms of which are known to predict premature ovarian failure, could be used to predict at what age a woman’s fertility is going to start decreasing,” he added.
The study also supports the belief that autoimmunity (immunity to one’s own cells or tissues) plays a role in infertility – a controversial topic among reproductive medicine specialists.
The study involved 339 female infertility patients who underwent a total of 455 IVF cycles at CHR. The researchers investigated the relationship between three different FMR1 genotypes and pregnancy outcomes and autoimmunity levels. Women with the “normal” FMR1 genotype had a 38.6 percent pregnancy rate; those with the “heterozygous-normal/high” genotype had a 31.7 percent pregnancy rate; and women found to have the “heterozygous-normal/low” genotype had a 22.2 percent pregnancy rate.
The genotype associated with the lowest pregnancy rate (heterozygous-normal/low) was also associated with increased measures of autoimmunity. Women with this genotype also had a higher incidence of polycystic ovary syndrome (a common cause of infertility), which is thought to have an autoimmune component. “Previous studies have suggested that autoimmunity plays a role in infertility,” said Dr. Barad. “Now, for the first time, we have a potential genetic mechanism that underlies several different threats to infertility.”
The cost of the blood test for the FMR1 should be relatively low – comparable to screening tests for Tay-Sachs and other genetic diseases. While the FMR1 gene test is not yet clinically available, “It’s likely that the findings will lead to clinical applications in the future,” said Dr. Barad.
“Any test that is proven to have predictive value for a woman’s fertility would give her a heads up in terms of planning a family,” he added. “For instance, if a woman planning to go to law school or medical school learns she has a certain amount of risk of losing her ovarian function before she is 35, she may choose to bank her eggs or try having children at an earlier age, rather than delay.”
Dr. Barad’s paper, “FMR1 Genotype with Autoimmunity-Associated Polycystic Ovary-Like Phenotype and Decreased Pregnancy Chance,” was published in the December 2010 issue of the online journal PLoS One. The other senior author is Norbert Gleicher, M.D., of Yale School of Medicine and CHR.About Albert Einstein College of Medicine of Yeshiva University
Kim Newman | Newswise Science News
High-arctic butterflies shrink with rising temperatures
07.10.2015 | Aarhus University
Long-term contraception in a single shot
07.10.2015 | California Institute of Technology
Der Forschungsreaktor TRIGA an der Johannes Gutenberg-Universität Mainz (JGU) hat zwei Monate nach den Feierlichkeiten zu seinem 50-jährigen Bestehen einen...
Für die MICADO-Kamera, das Instrument mit dem das European Extremely Large Telescope (E-ELT) seine ersten Bilder machen wird, beginnt eine neue Phase: In einer gemeinsamen Absichtserklärung (Memorandum of Understanding) auf der „Kick-off“-Konferenz in Wien bestätigten die Partner in Deutschland, Frankreich, den Niederlanden, Österreich und Italien ihre Teilnahme am Projekt. Zwei Wochen zuvor, am 18. September, hatten das Konsortium und die Europäische Südsternwarte (ESO), die das Teleskop baut, den entsprechenden Kooperationsvertrag unterzeichnet. Nach diesen Meilensteinen tritt das Projekt nun in die Designphase ein.
Als erste, dedizierte Kamera für das E-ELT wird MICADO beugungsbegrenzte Abbildungen bei Nah-Infrarot-Wellenlängen (Wärmestrahlung) mit dem Riesenteleskop...
The MICADO camera, a first light instrument for the European Extremely Large Telescope (E-ELT), has entered a new phase in the project: by agreeing to a Memorandum of Understanding, the partners in Germany, France, the Netherlands, Austria, and Italy, have all confirmed their participation. Following this milestone, the project's transition into its preliminary design phase was approved at a kick-off meeting held in Vienna. Two weeks earlier, on September 18, the consortium and the European Southern Observatory (ESO), which is building the telescope, have signed the corresponding collaboration agreement.
As the first dedicated camera for the E-ELT, MICADO will equip the giant telescope with a capability for diffraction-limited imaging at near-infrared...
Self-driving cars will be on our streets in the foreseeable future. In Graz, research is currently dedicated to an innovative driver assistance system that takes over control if there is a danger of collision. It was nature that inspired Dr Manfred Hartbauer from the Institute of Zoology at the University of Graz: in dangerous traffic situations, migratory locusts react around ten times faster than humans. Working together with an interdisciplinary team, Hartbauer is investigating an affordable collision detector that is equipped with artificial locust eyes and can recognise potential crashes in time, during both day and night.
Inspired by insects
Selbstfahrende Autos könnten in absehbarer Zukunft auf unseren Straßen unterwegs sein. Ein innovativer Fahrzeugassistent, der bei Kollisionsgefahr das Steuer übernimmt, wird gerade in Graz erforscht. Manfred Hartbauer vom Institut für Zoologie der Karl-Franzens-Universität hat sich die Basis dafür in der Natur abgeschaut: Wanderheuschrecken können in brenzligen Verkehrssituationen etwa zehnmal schneller reagieren als Menschen. In Zusammenarbeit mit einem interdisziplinären Team erforscht er einen kostengünstigen Kollisionsdetektor, der mit künstlichen Heuschrecken-Augen ausgestattet ist und drohende Zusammenstöße bei Tag und Nacht rechtzeitig erkennen kann.
08.10.2015 | Veranstaltungen
08.10.2015 | Veranstaltungen
08.10.2015 | Veranstaltungen
08.10.2015 | Kommunikation Medien
08.10.2015 | Energie und Elektrotechnik
08.10.2015 | Physik Astronomie