Adipose-derived stem cells maintain their "stemness" and could be useful for cell-based therapies A team of researchers from several institutions in Italy isolated and characterized adult fat cell-derived stem cells from patients undergoing lipoaspiration (surgical removal of fat deposits) in order to investigate the ability of the fat cells to maintain their stem cell characteristics in in vitro cultures to the point where once transplanted they could aid in tissue regeneration.
According to the study's corresponding authors Dr. Stefami Bucher of the San Gallicano Institute (Rome) and Dr. Rita Falcioni of the Regina Elena Cancer Institute (Rome), adipose tissues share several biological properties with bone marrow, they can be found in abundance, they can be obtained from patients undergoing noninvasive lipoaspirate procedures, and they have the potential to be useful in a range of therapeutic applications.
"The use of lipoaspirate as filling material is a powerful technique for tissue repair in plastic surgery," said Dr. Falcioni. "Increasingly, it is used in oncology to repair tissue damaged by surgical treatments, such as mastectomy. The use of purified adipose-derived stem cells might improve this surgical procedure by shortening the time to achieve esthetic results and thereby improving patient quality of life."
The researchers described adipose tissues as "highly specialized connective tissues" that help provide the body with an energy source, yet little research has investigated the transplant potential of adipose-derived stem cells.
"We strongly suggest that the adipose-derived stem cells we purified in our study could be applied in the near future for cell therapy using the cell-assisted lipotransfer technique."
Contact: Dr. Rita Falcioni, Regina Elena Cancer Institute, Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro, 156, 00158 Rome, Italy Tel:+ 39-06- 52662535; Fax: +39-06-52662505 Email: firstname.lastname@example.org
Citation: Folgiero, V.; Migliano, E.; Tedesco, M.; Iacovelli, S.; Bon, G.; Torre, M. L.; Sacchi, A.; Marazzi, M.; Bucher, S.; Falcioni, R. Purification and characterization of adipose-derived stem cells from patients with lipoaspirate transplant. Cell Transplant. 19(10):1225-1235; 2010.
Plastic surgery meets regenerative medicine
"Progenitor, endothelial and mensenchymal stem cells derived from adipose tissues could be central to plastic and reconstructive surgery applications as well as represent the focus for therapies for a number of disease conditions, including those affecting bone, cartilage, muscle, liver, kidney, cardiac, neural and pancreatic tissue," said Dr. Camillo Ricordi, lead author on a paper by researchers from the University of Miami's Cell Transplant Center and Diabetes Research Institute.
According to Dr. Ricordi and colleagues, successful engraftment and long term survival of transplanted adipose tissue has increased interest in structural fat grafting, yet there is a high percentage (up to 70%) of tissue resorption over time. Adipose cells can also fall victim to trauma during harvesting. In contrast, progenitor cells have minimal metabolic requirements and tend to survive longer.
"Adipose-derived stem cells might very well represent the only tissue surviving transplantation," concluded Dr. Ricordi. "There is much more to be learned in tissue remodeling following adipose tissue transplantation and it is time to carefully re-examine the potential implications of autologous fat grafting as being more than the filler concept for which it was originally utilized."
"These two articles highlight the considerable promise for therapeutic and cosmetic benefit from the relatively new derivation of stem cells from fat cells," said Dr. Paul Sanberg, co-editor-in-chief of the journal Cell Transplantation and executive director of the University of South Florida Center of Excellence for Aging and Brain Repair. "It will be of great interest to see how the clinical use of these cells will develop."
Contact: Dr. Camillo Ricordi, Cell Transplant Center and Diabetes Research Institute, University of Miami, 1450 NW 10th Ave., Miami, FL, USA 33136, Tel:+ 305-243-4404; Fax: 305-243-6913 Email: email@example.com
Citation: Tremolada, C.; Palmieri, G.; Ricordi, C. Adipocyte Transplantation and Stem Cells: Plastic Surgery Meets Regenerative Medicine. Cell Transplant. 19(10):1217-1223; 2010.
The editorial offices for Cell Transplantation are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. Contact, David Eve, PhD. at firstname.lastname@example.org or Camillo Ricordi, MD at email@example.com
News Release by Randolph Fillmore, Florida Science Communications, Inc. www.sciencescribe.net
Learning from Nature: Genomic database standard alleviates search for novel antibiotics
02.09.2015 | Max-Planck-Institut für marine Mikrobiologie
Orang-utan females prefer cheek-padded males
02.09.2015 | Max Planck Institute for Evolutionary Anthropology, Leipzig
Kohlenstoffkäfige polymerisieren in Kohlenstoffnanoröhren zu einer linearen nanodiamantenartigen Kette
Im Innenraum von Kohlenstoffnanoröhren gezielt ein lineares Polymer aus nanodiamantenartigen Bausteinen zu gewinnen – das gelang Forschern aus Japan,...
Rauchmelder sind allgegenwärtig. Dennoch geht die Zahl der Brandopfer jährlich in die Tausende. Brandgasmelder, die auf Kohlenstoffmonoxid und Stickoxide reagieren, entdecken Brände im Frühstadium. Durch ein neues Messprinzip von Fraunhofer-Forschern werden die teuren Sensoren nun kostengünstig und damit bereit für den Massenmarkt.
Die Sterne funkeln am Himmel, die Bewohner des Hauses schlummern in ihren Betten. Soweit nichts Besonderes, doch in dieser Nacht steht ihr Leben auf dem Spiel:...
China's Loess Plateau was formed by wind alternately depositing dust or removing dust over the last 2.6 million years, according to a new report from University of Arizona geoscientists. The study is the first to explain how the steep-fronted plateau formed.
China's Loess Plateau was formed by wind alternately depositing dust or removing dust over the last 2.6 million years, according to a new report from...
Davon träumt die Wissenschaft: An einem Computer zu simulieren, wie sich das Universum bis heute entwickelt hat. Forscher aus Würzburg und Heidelberg wollen dem Traum jetzt näher kommen: Sie haben Rechenzeit im Wert von knapp fünf Millionen Euro auf einem Supercomputer bewilligt bekommen.
Der Würzburger Mathematiker Professor Christian Klingenberg und der Heidelberger Astrophysiker Professor Volker Springel haben sich Großes vorgenommen: Sie...
The leaves of the lotus flower, and other natural surfaces that repel water and dirt, have been the model for many types of engineered liquid-repelling surfaces. As slippery as these surfaces are, however, tiny water droplets still stick to them. Now, Penn State researchers have developed nano/micro-textured, highly slippery surfaces able to outperform these naturally inspired coatings, particularly when the water is a vapor or tiny droplets.
Enhancing the mobility of liquid droplets on rough surfaces could improve condensation heat transfer for power-plant heat exchangers, create more efficient...
02.09.2015 | Veranstaltungen
02.09.2015 | Veranstaltungen
02.09.2015 | Veranstaltungen
02.09.2015 | Ökologie Umwelt- Naturschutz
02.09.2015 | Biowissenschaften Chemie
02.09.2015 | Förderungen Preise