Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Detecting Cocaine “Naturally”

15.02.2013
Canada-US-Italian research team develops a cocaine biosensor inspired from nature

Since the beginning of time, living organisms have developed ingenious mechanisms to monitor their environment. As part of an international study, a team of researchers has adapted some of these natural mechanisms to detect specific molecules such as cocaine more accurately and quickly. Their work may greatly facilitate the rapid screening—less than five minutes—of many drugs, infectious diseases, and cancers.


University of Montreal

Artist’s rendering: The research team used an existing cocaine biosensor (in green) and revised its design to react to a series of inhibitor molecules (in blue). They were able to adapt the biosensor to respond optimally even within a large concentration window.

Professor Alexis Vallée-Bélisle of the University of Montreal Department of Chemistry has worked with Professor Francesco Ricci of the University of Rome Tor Vergata and Professor Kevin W. Plaxco of the University of California at Santa Barbara to improve a new biosensing nanotechnology. The results of the study were recently published in the Journal of American Chemical Society (JACS).

Toward a new generation of screening tests

"Nature is a continuing source of inspiration for developing new technologies,” says Professor Francesco Ricci, senior author of the study. “Many scientists are currently working to develop biosensor technology to detect—directly in the bloodstream and in seconds—drug, disease, and cancer molecules."

“The most recent rapid and easy-to-use biosensors developed by scientists to determine the levels of various molecules such as drugs and disease markers in the blood only do so when the molecule is present in a certain concentration, called the concentration window,” adds Professor Vallée-Bélisle. "Below or above this window, current biosensors lose much of their accuracy.”

To overcome this limitation, the international team looked at nature: “In cells, living organisms often use inhibitor or activator molecules to automatically program the sensitivity of their receptors (sensors), which are able to identify the precise amount of thousand of molecules in seconds,” explains Professor Vallée-Bélisle. “We therefore decided to adapt these inhibition, activation, and sequestration mechanisms to improve the efficiency of artificial biosensors.”

The researchers put their idea to the test by using an existing cocaine biosensor and revising its design so that it would respond to a series of inhibitor molecules. They were able to adapt the biosensor to respond optimally even with a large concentration window. “What is fascinating,” says Alessandro Porchetta, a doctoral student at the University of Rome, “is that we were successful in controlling the interactions of this system by mimicking mechanisms that occur naturally.”

“Besides the obvious applications in biosensor design, I think this work will pave the way for important applications related to the administration of cancer-targeting drugs, an area of increasing importance," says Professor Kevin Plaxco. “The ability to accurately regulate biosensor or nanomachine’s activities will greatly increase their efficiency.”

References on the study

The research was funded by the Italian Ministry of Universities and Research (MIUR), the Bill & Melinda Gates Foundation Grand Challenges Explorations program, the European Commission Marie Curie Actions program, the U.S. National Institutes of Health, and the Fonds de recherche du Québec Nature et Technologies.

On the Web:
 The article Using Distal-Site Mutations and Allosteric Inhibition To Tune, Extend, and Narrow the Useful Dynamic Range of Aptamer-Based Sensors was published in the Journal of the American Chemical Society.
 The laboratory of Professor Alexis Vallée-Bélisle: www.nanomachineslab.org
 The laboratory of Professor Francesco Ricci: www.francescoriccilab.com
 The laboratory of Professor Kevin Plaxco: http://web.chem.ucsb.edu/~plaxcogroup/

 Université of Montreal Department of Chemistry : www.chimie.umontreal.ca

Notes: The University of Montreal is officially known as Université de Montréal.

Media Contact
Julie Gazaille
Press Attachée, University of Montreal
+ 1 514 343-6796 j.cordeau-gazaille@umontreal.ca

Julie Gazaille | Newswise
Further information:
http://www.umontreal.ca

More articles from Life Sciences:

nachricht A 'movie' of ultrafast rotating molecules at a hundred billion per second
06.07.2015 | National Institutes of Natural Sciences

nachricht First Comprehensive Analysis of the Woolly Mammoth Genome Completed
06.07.2015 | University of Chicago Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Windturbinen unter Brücken sind sinnvoll

Ansatz für dicht verbaute oder schützenswerte Gebiete attraktiv

Laut einem spanisch-britischen Forscherteam wäre es sinnvoll, unter großen Brücken Windturbinen zur Stromgewinnung zu verbauen. Denn Modellrechnungen am...

Im Focus: Forschungsschiff Heincke seit 25 Jahren im Dienst der Wissenschaft

Ein Vierteljahrhundert alt, über 900.000 Kilometer (488.842 nautische Meilen) gefahren und trotzdem auf dem neuesten wissenschaftlichen und technischen Stand: Die Indienststellung des Forschungsschiffes Heincke jährt sich am 8. Juli 2015 zum 25. Mal.

Wissenschaftler des Alfred-Wegener-Instituts, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), das die Heincke betreibt, nehmen ebenso regelmäßig an...

Im Focus: Solardächer produzieren Strom für Fahrzeuge

Studentische Industriekooperation zwischen HAW Hamburg und Webasto erarbeitet Ergebnisse für EU-Zertifizierungsprozess von Solardächern zur Verbesserung der Öko-Bilanz von Fahrzeugen.

Unter der Leitung von Dr.-Ing. Volker Skwarek, Professor für technische Informatik an der HAW Hamburg, erarbeiteten sechs Studierende des...

Im Focus: Viaducts with wind turbines, the new renewable energy source

Wind turbines could be installed under some of the biggest bridges on the road network to produce electricity. So it is confirmed by calculations carried out by a European researchers team, that have taken a viaduct in the Canary Islands as a reference. This concept could be applied in heavily built-up territories or natural areas with new constructions limitations.

The Juncal Viaduct, in Gran Canaria, has served as a reference for Spanish and British researchers to verify that the wind blowing between the pillars on this...

Im Focus: Aus alt mach neu - Rohstoffquelle Elektroschrott

Der Markt für Unterhaltungselektronik boomt: Rund 60 Millionen Fernsehgeräte wurden im letzten Jahr in Europa verkauft. Früher oder später werden sie zurückkehren – als Elektroschrott.

Die Recycling-Industrie hat darauf reagiert: Kupfer, Aluminium, Eisen- und Edelmetalle sowie ausgewählte Kunststoffe werden bereits wiederverwertet. Allerdings...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Rheumatologen tagen in Bremen: Fortschritte in der Rheuma-Therapie und neue Impfempfehlungen

06.07.2015 | Veranstaltungen

9. Aachener Technologie- und Innovationsmanagement-Tagung

06.07.2015 | Veranstaltungen

Flurförderzeuge im Zeichen der Zeit

03.07.2015 | Veranstaltungen

 
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Pepper – der empathische Roboter

06.07.2015 | Energie und Elektrotechnik

Erfolgreich: Zement auf Kohlendioxid

06.07.2015 | Geowissenschaften

3 Mio. Euro für Regensburger Forschungsprojekt – Startschuss für Internetkompetenzzentrum Ostbayern

06.07.2015 | Förderungen Preise