Our wide range of nanocoatings is not only available for SPR sensordiscs and ASI sensorchips but can be applied to other substrates as well. A flexible surface modification process allows the derivatization of many other materials with exactly defined biocoatings - such as planar monolayers or three-dimensional hydrogels with thicknesses ranging from a few nm up to one µm. You can choose from a great variety of coating materials and chemical functionalities from which a large part is listed in the sensorchip section. In addition to that, we are able to coat other substrates with different substances according to your specifications.
A selection of coatable substrate materials is listed below:
Metals and Alloys
Transition metals of IUPAC groups 4 - 11
The above-mentioned nanomodifications have a great variety of applications to control surface properties of bulk materials. Some examples are:
Surgical and blood processing biomedical devices and implants coated with polysaccharide or polyethyleneglycol layers show a greatly enhanced biocompatibility. Implant rejection and thrombosis can be reduced immensely or even be eliminated. As our bioinert nanolayers stabilize surfaces again protein adsorption, they can be applied to good effect to bioanalytical devices where the suppression of nonspecific interactions is one of the major bottlenecks. We are able to coat ELISA plates, biochip and sensor surfaces as well as the channels of miniaturized flow systems for lab-on-a-chip applications.
In addition to a simple bioinertization, we can integrate functional biomolecules into our coatings. To give an example, cell specific growth and adhesion factors can be immobilized. For one, such coatings might be used in vivo to trigger the growth of a specific tissue. For another, you can use them ex vivo to create biocompatible walls of cell culture containers.
Our polysaccharide nanolayers provide an excellent matrix for the covalent immobilization of proteins, peptides, nucleic acids and even small organic molecules. Using them, the immobilization capacity of surfaces is up to ten times higher than that of non-coated substrates. The immobilization process is very efficient and usually does not denaturate even sensitive biomolecules. Moreover, these surfaces are fully regenerable, i.e. it is possible to almost completely remove bound molecules which have interacted with the immobilized substance.
Coating of ophtalmic devices
As our polysaccharide nanolayers behave like thin hydrogels, they are able to bind a considerable amount of water. They also have a lubricating effect caused by their high surface energy. Thus, they are ideally suited for the coating of contact lenses: not only do they prevent the lens surface from being spoilt by cell debris, cosmetics, dust and dirt, solvent vapors and chemicals. They also provide a continuous layer of tear fluid on the contact lens between the blinks of the eye. This layer lubricates the tissue/lens interface and thus prevents soreness of the eyes and unwanted movement of the contact lens. Thereby, the wearing comfort of coated contact lenses is much higher than that of untreated lenses.
Due to a high surface energy and an entropy-caused stabilizing effect of the hydrophilic polymer chains, our coatings prevent surfaces from adsorbing dirt from aequous solutions. Contaminations can be easily washed away with water - usually without using detergents.
coatings The hydrogel layers’ hydrophilicity and their ability to retain water cause very low contact angles - usually between 0° and 10°. Water condensing on surfaces that are coated forms no droplets any more but a homogeneous film which does not affect the material’s optical quality. That is why our anti-condensation coatings are well suited for optical devices which are operated in wet and humid environments and under conditions with drastic temperature changes.
Lubrication - especially that of miniaturized systems which are to function in an aequous environment - is often a difficult task. Coating parts of such systems with nano-sized hydrogel layers drastically reduces friction and also prevents the adsorption of dirt and biological contaminants. For instance, lubricating coatings can be applied to instruments for minimal invasive surgery and to microsystems for bioanalytical purposes.
In a nutshell, the examples given above illustrate a selection of possible uses. Contact us for more information. We are happy to learn about new applications and to discuss how we can use our know-how in order to optimize the quality of your products
xantec | xantec
Weitere Berichte zu: > Coatings
Wie Reize auf dem Weg ins Bewusstsein versickern
22.09.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Lebendiges Gewebe aus dem Drucker
22.09.2017 | Universitätsklinikum Freiburg
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Es ist noch immer weitgehend unbekannt, wie die komplexen neuronalen Netzwerke im Gehirn aufgebaut sind. Insbesondere in der Hirnrinde der Säugetiere, wo Sehen, Denken und Orientierung berechnet werden, sind die Regeln, nach denen die Nervenzellen miteinander verschaltet sind, nur unzureichend erforscht. Wissenschaftler um Moritz Helmstaedter vom Max-Planck-Institut für Hirnforschung in Frankfurt am Main und Helene Schmidt vom Bernstein-Zentrum der Humboldt-Universität in Berlin haben nun in dem Teil der Großhirnrinde, der für die räumliche Orientierung zuständig ist, ein überraschend präzises Verschaltungsmuster der Nervenzellen entdeckt.
Wie die Forscher in Nature berichten (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005), haben die...
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Graphen besitzt extreme Eigenschaften und ist vielseitig verwendbar. Mit einem Trick lassen sich sogar die Spins im Graphen kontrollieren. Dies gelang einem HZB-Team schon vor einiger Zeit: Die Physiker haben dafür eine Lage Graphen auf einem Nickelsubstrat aufgebracht und Goldatome dazwischen eingeschleust. Im Fachblatt 2D Materials zeigen sie nun, warum dies sich derartig stark auf die Spins auswirkt. Graphen kommt so auch als Material für künftige Informationstechnologien infrage, die auf der Verarbeitung von Spins als Informationseinheiten basieren.
Graphen ist wohl die exotischste Form von Kohlenstoff: Alle Atome sind untereinander nur in der Ebene verbunden und bilden ein Netz mit sechseckigen Maschen,...
22.09.2017 | Veranstaltungen
22.09.2017 | Veranstaltungen
21.09.2017 | Veranstaltungen
22.09.2017 | Veranstaltungsnachrichten
22.09.2017 | Förderungen Preise
22.09.2017 | Biowissenschaften Chemie