Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

The gene that turns ponies into large horses

14.02.2013
TiHo researchers discover genetic causes of the body sizes of horses

Ponies have a maximum height of 148 centimetres. When the height at the withers is greater, they are deemed to be large horses. Scientists at the Institute for Animal Breeding and Genetics at University of Veterinary Medicine Hannover (TiHo) have investigated genetic causes for different body sizes in horses and found a gene with a very strong impact on size.

The researchers compared thousands of genetic variations between ponies and larger horses to determine whether a specific mutation is responsible for size differences in horses. Such point mutations on single nucleotide polymorphisms (SNPs) are the most common causes of genetic variations. Scientists then used gene expression analysis to identify a gene that has a crucial effect on the size development of horses. The results have been published in PloS One, an international specialised journal, at http://dx.plos.org/10.1371/journal.pone.0056497.

The growth of the horses is determined by a mutation that influences the LCORL (ligand-dependent nuclear receptor compressor-like protein) gene. This mutation has the effect that the gene is not read as often in large horses as it is in ponies. "We conclude from these findings that LCORL limits size growth in horses. The more strongly LCORL is expressed, the smaller the horses are" said Professor Dr Ottmar Distl, the head of the Institute for Animal Breeding and Genetics at TiHo. All original Przewalski wild horses carried the pony mutation and purebred Arab horses also have only this genetic variant.

Warmblood horses show a greater variation of the height at the withers and have a great genetic variation. Almost half of this variation is due to regulatory mutation affecting LCORL. The smaller warmblood horses are homozygous for the pony mutation. Warmblood horses in the medium-sized range carry both genetic variants and are therefore heterozygous, while large warmblood horses are homozygous for the large horse mutation.

The large coldblood horse breeds such as the Rhenish-German Coldblood, the Saxon-Thuringia Coldblood, the Noriker and the South-German Coldblood do not include animals with the homozygous pony mutation and only a few of them are heterozygous. "The distribution of the pony mutation in the different horse breeds suggests that the mutation prevailing in large horses arose during the domestication of horses in Western Europe," explained Professor Distl.

LCORL influences the torso and hip length in humans, but does not act as a major regulator for size. However, scientists assume that LCORL has a very strong effect on the size of horses. There are also other genes involved in the complex characteristic "body size" and the scientists plan to investigate these genes in further studies.

Horse breeders can use these new findings for their breeding decisions. The Institute for Animal Breeding and Genetics at TiHo offers gene testing for this purpose. Further information is provided on the institute's website: www.tiho-hannover.de/kliniken-institute/institute/institur-fuer-tierzucht-und-vererbungsforschung /dienstleistungen/gentest/gentests-pferd/

For specialised queries, please contact:

Professor Dr. Ottmar Distl
University of Veterinary Medicine Hannover
Institute for Animal Breeding and Genetics
Tel.: +49 511 953-8875
ottmar.distl@tiho-hannover.de

Sonja von Brethorst | idw
Further information:
http://www.tiho-hannover.de

More articles from Agricultural and Forestry Science:

nachricht Climate change, population growth may lead to open ocean aquaculture
05.10.2017 | Oregon State University

nachricht New machine evaluates soybean at harvest for quality
04.10.2017 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Topologische Isolatoren: Neuer Phasenübergang entdeckt

Physiker des HZB haben an BESSY II Materialien untersucht, die zu den topologischen Isolatoren gehören. Dabei entdeckten sie einen neuen Phasenübergang zwischen zwei unterschiedlichen topologischen Phasen. Eine dieser Phasen ist ferroelektrisch: das bedeutet, dass sich im Material spontan eine elektrische Polarisation ausbildet, die sich durch ein äußeres elektrisches Feld umschalten lässt. Dieses Ergebnis könnte neue Anwendungen wie das Schalten zwischen unterschiedlichen Leitfähigkeiten ermöglichen.

Topologische Isolatoren zeichnen sich dadurch aus, dass sie an ihren Oberflächen Strom sehr gut leiten, während sie im Innern Isolatoren sind. Zu dieser neuen...

Im Focus: Smarte Sensoren für effiziente Prozesse

Materialfehler im Endprodukt können in vielen Industriebereichen zu frühzeitigem Versagen führen und den sicheren Gebrauch der Erzeugnisse massiv beeinträchtigen. Eine Schlüsselrolle im Rahmen der Qualitätssicherung kommt daher intelligenten, zerstörungsfreien Sensorsystemen zu, die es erlauben, Bauteile schnell und kostengünstig zu prüfen, ohne das Material selbst zu beschädigen oder die Oberfläche zu verändern. Experten des Fraunhofer IZFP in Saarbrücken präsentieren vom 7. bis 10. November 2017 auf der Blechexpo in Stuttgart zwei Exponate, die eine schnelle, zuverlässige und automatisierte Materialcharakterisierung und Fehlerbestimmung ermöglichen (Halle 5, Stand 5306).

Bei Verwendung zeitaufwändiger zerstörender Prüfverfahren zieht die Qualitätsprüfung durch die Beschädigung oder Zerstörung der Produkte enorme Kosten nach...

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

DFG unterstützt Kongresse und Tagungen - Dezember 2017

17.10.2017 | Veranstaltungen

Intelligente Messmethoden für die Bauwerkssicherheit: Fachtagung „Messen im Bauwesen“ am 14.11.2017

17.10.2017 | Veranstaltungen

Meeresbiologe Mark E. Hay zu Gast bei den "Noblen Gesprächen" am Beutenberg Campus in Jena

16.10.2017 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Mikroben hinterlassen "Fingerabdrücke" auf Mars-Gestein

17.10.2017 | Biowissenschaften Chemie

Vorhersagen bestätigt: Schwere Elemente bei Neutronensternverschmelzungen nachgewiesen

17.10.2017 | Physik Astronomie

Kaiserschnitt-Risiko ist vererbbar

17.10.2017 | Biowissenschaften Chemie