Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Scientists Discover Mechanism That Could Reduce Obesity

06.12.2012
Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses.
But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2). In their experiments, the scientists discovered that Tyk2 helps regulate obesity in mice and humans through the differentiation of a type of fat tissue known as brown adipose tissue (BAT).

Published today in the online edition of the journal Cell Metabolism, the study is the first to provide evidence of the relationship between Tyk2 and BAT. Previous studies by Larner and his team discovered that Tyk2 helps suppress the growth and metastasis of breast cancer, and now the current study suggests this same enzyme could help protect against and even reverse obesity.

The scientists were able to reverse obesity in mice that do not express Tyk2 by expressing a protein known as signal transducer and activator of transcription-3 (Stat3). Stat3 mediates the expression of a variety of genes that regulate a host of cellular processes. The researchers found that Stat3 formed a complex with a protein known as PR domain containing 16 (PRDM16) to restore the development of BAT and decrease obesity.

“We discovered that Tyk2 levels in mice are regulated by diet. We then tested tissue samples from humans and found that levels of Tyk2 were more than 50 percent lower in obese humans,” said Larner, Martha Anne Hatcher Distinguished Professor in Oncology and co-leader of the Cancer Cell Signaling program at VCU Massey Cancer Center. “Our findings open new potential avenues for research and development of new pharmacological and nutritional treatments for obesity.”

There are two different types of fat – white adipose tissue (WAT) and BAT. WAT is the primary site of energy storage. BAT is responsible for energy expenditure in order to maintain body temperature. BAT deposits are present in all mammals, but until recently, scientists thought BAT was only active in infants and not in adult humans. Only in the last four years have scientists realized that BAT is present in adults and helps to regulate energy expenditure. Additionally, research has shown that diminished BAT activity is associated with metabolic syndrome, a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. Researchers estimate metabolic syndrome could affect as much as 25 percent of the U.S. population.

“We have made some very interesting observations in this study, but there are many questions left unanswered,” said Larner. “We plan to further investigate the actions of Tyk2 and Stat3 in order to better understand the mechanisms involved in the development of brown adipose tissue. We’re hopeful this research will help lead to new targets to treat a variety of obesity-related diseases such as cancer, cardiovascular disease and diabetes.”

Larner collaborated on this study with Marta Derecka, Magdalena Morgan, Vidisha Raje, Jennifer Sisler and Quifang Zhang, all from the Department of Biochemistry and Molecular Biology at VCU School of Medicine; Tomasz Kordula, Ph.D., Cancer Cell Signaling program member at VCU Massey; Agnieszka Gornicka, from the Cleveland Clinic Foundation; Sergei B. Koralov, Ph.D., from New York University Medical School; Dennis Otero, Ph.D., from the University of California; Joanna Cichy, Ph.D., from Jagiellonian University in Krakow, Poland; Klaus Rajewsky, Ph.D., from Harvard Medical School; Kazuya Shimoda, M.D., Ph.D., from Miyazaki University in Japan; Valeria Poli, Ph.D., from the University of Turin in Torino, Italy; Brigit Strobl, Ph.D., from the University of Veterinary Medicine in Vienna, Austria; Sandra Pellegrini, Ph.D., from Institut Pasteur in Paris, France; Thurl E. Harris, Ph.D., and Susanna R. Keller, M.D., from University of Virginia School of Medicine; Patrick Seale, Ph.D., from the University of Pennsylvania School of Medicine; Aaron P. Russell, Ph.D., from Deakin University in Burwood, Australia; Andrew J. McAinch, Ph.D., from Victoria University in St. Albans, Australia; Paul E. O’Brien, M.D., from Monash University in Melbourne, Australia; and Colleen M. Croniger, Ph.D., from Case Western University School of Medicine.

This study was supported by National Institutes of Health grants R01 AI059710-01 and R21 AI088487, the Austrian Science Fund and, in part, by funding from VCU Massey Cancer Center's NIH-NCI Cancer Center Support Grant P30 CA016059.

News directors: Broadcast access to VCU Massey Cancer Center experts is available through VideoLink ReadyCam. ReadyCam transmits video and audio via fiber optics through a system that is routed to your newsroom. To schedule a live or taped interview, contact John Wallace, (804) 628-1550.
About the VCU Massey Cancer Center
VCU Massey Cancer Center is one of only 66 National Cancer Institute-designated institutions in the country that leads and shapes America’s cancer research efforts. Working with all kinds of cancers, the Center conducts basic, translational and clinical cancer research, provides state-of-the-art treatments and clinical trials, and promotes cancer prevention and education. Since 1974, Massey has served as an internationally recognized center of excellence. It offers a wide range of clinical trials throughout Virginia, oftentimes the most trials in the state, and serves patients in Richmond and in four satellite locations. Its 1,000 researchers, clinicians and staff members are dedicated to improving the quality of human life by developing and delivering effective means to prevent, control and ultimately to cure cancer. Visit Massey online at www.massey.vcu.edu or call 877-4-MASSEY for more information.
About VCU and the VCU Medical Center
Virginia Commonwealth University is a major, urban public research university with national and international rankings in sponsored research. Located in downtown Richmond, VCU enrolls more than 31,000 students in 222 degree and certificate programs in the arts, sciences and humanities. Sixty-six of the programs are unique in Virginia, many of them crossing the disciplines of VCU’s 13 schools and one college. MCV Hospitals and the health sciences schools of Virginia Commonwealth University compose the VCU Medical Center, one of the nation’s leading academic medical centers.

John Wallace | EurekAlert!
Further information:
http://www.vcu.edu

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Forscher entwickeln quantenphotonischen Schaltkreis mit elektrischer Lichtquelle

Optische Quantenrechner könnten die Computertechnologie revolutionieren. Forschern um Wolfram Pernice von der Westfälischen Wilhelms-Universität Münster sowie Ralph Krupke, Manfred Kappes und Carsten Rockstuhl vom Karlsruher Institut für Technologie ist es nun gelungen, einen quantenoptischen Versuchsaufbau auf einem Chip zu platzieren. Damit haben sie eine Voraussetzung erfüllt, um photonische Schaltkreise für optische Quantencomputer nutzbar machen zu können.

Ob für eine abhörsichere Datenverschlüsselung, die ultraschnelle Berechnung riesiger Datenmengen oder die sogenannte Quantensimulation, mit der hochkomplexe...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: Quantenboost für künstliche Intelligenz

Intelligente Maschinen, die selbständig lernen, gelten als Zukunftstrend. Forscher der Universität Innsbruck und des Joint Quantum Institute in Maryland, USA, loten nun in der Fachzeitschrift Physical Review Letters aus, wie Quantentechnologien dabei helfen können, die Methoden des maschinellen Lernens weiter zu verbessern.

In selbstfahrenden Autos, IBM's Watson oder Google's AlphaGo sind Computerprogramme am Werk, die aus Erfahrungen lernen können. Solche Maschinen werden im Zuge...

Im Focus: Synthese-chemischer Meilenstein: Neues Ferrocenium-Molekül entdeckt

Wissenschaftler der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) haben zusammen mit Kollegen der Freien Universität Berlin ein neues Molekül entdeckt: Die Eisenverbindung in der seltenen Oxidationsstufe +4 gehört zu den Ferrocenen und ist äußerst schwierig zu synthetisieren.

Metallocene werden umgangssprachlich auch als Sandwichverbindungen bezeichnet. Sie bestehen aus zwei organischen ringförmigen Verbindungen, den...

Im Focus: Neue Entwicklungen in der Asphären-Messtechnik

Kompetenzzentrum Ultrapräzise Oberflächenbearbeitung (CC UPOB) lädt zum Expertentreffen im März 2017 ein

Ob in Weltraumteleskopen, deren Optiken trotz großer Abmessungen nanometergenau gefertigt sein müssen, in Handykameras oder in Endoskopen − Asphären kommen in...

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Laser für Neurochirurgie und Biofabrikation - LaserForum 2016 thematisiert Medizintechnik

27.09.2016 | Veranstaltungen

Ist Vergessen die Zukunft?

27.09.2016 | Veranstaltungen

Von der Probe zum digitalen Modell - MikroskopieTrends ´16

26.09.2016 | Veranstaltungen

 
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Nanotechnologie für Energie-Materialien: Elektroden wie Blattadern

27.09.2016 | Physik Astronomie

Ultradünne Membranen aus Graphen

27.09.2016 | Physik Astronomie

Ein magnetischer Antrieb für Mikroroboter

27.09.2016 | Biowissenschaften Chemie