Forum für Wissenschaft, Industrie und Wirtschaft

Hauptsponsoren:     3M 
Datenbankrecherche:

 

Researchers sequence swine genome, discover associations that may advance animal and human health

16.11.2012
An international scientific collaboration that includes two Kansas State University researchers is bringing home the bacon when it comes to potential animal and human health advancements, thanks to successfully mapping the genome of the domestic pig.

The sequenced genome gives researchers a genetic blueprint of the pig. It includes a complete list of DNA and genes that give pigs their traits like height and color. Once all of the genetic information is understood, scientists anticipate improvements to the animal's health as well as human health, as pigs and humans share similar physiologies.

"With the sequenced genome we have a better blueprint than we had before about the pig's genetics and how those genetic mechanisms work together to create, such as the unique merits in disease resistance," said Yongming Sang, research assistant professor of anatomy and physiology at Kansas State University.

For three years, Sang worked on the genome sequencing project with Frank Blecha, associate dean for the College of Veterinary Medicine and university distinguished professor of anatomy and physiology.

A report of the international study appears as the cover story for the Nov. 15 issue of the journal Nature.

The sequencing effort was led by the Swine Genome Sequencing Consortium. Researchers with the consortium invited Sang and Blecha to work on the project because of their expertise and published studies on the antimicrobial peptides and interferons that pigs use to genetically defend themselves against disease.

Sang and Blecha focused on these two families of immune genes, looking for gene duplications and gene-family expansions throughout the pig's 21,640 protein-coding genes, in an effort to help scientists with future pig-related research.

Sang also completed much of the genome annotation for Kansas State University's contributions. Genome annotation involves identifying, categorizing and recording the potential functions of thousands of individual genes and gene cluster locations in the pig genome.

Analysis revealed that the olfactory and cathelicidin gene families in pigs are more evolutionarily evolved than those in humans and many other animals. Pigs have a better sense of smell, which makes them experts at finding truffles, for example. Pigs also have twice as many interferon genes as humans, possibly indicating some unique immune mechanisms against viral infection, Sang said.

Researchers also discovered several health similarities between humans and pigs. Pigs share some of the same protein abnormalities as humans with obesity, diabetes, dyslexia, Parkinson's disease and Alzheimer's disease.

Similarly, researchers found that pigs have fewer endogenous retroviruses than many other animals, making pigs an important ally for more complex medical procedures like organ transplants.

"The pig genome is very important, maybe even more important than we once thought," Sang said. "It is very good for biomedical research advancements and it also looks to be a good resource for comparative studies of many other diseases."

At Kansas State University the sequenced pig genome stands to benefit agricultural, food animal and veterinary medicine research.

"For many years the pig has been one of the best models for human physiology and has been used extensively because of that," Blecha said. "While this is a blueprint for the health of the pig, it is also a blueprint for the expression of genes and how to modify them for perhaps better animal models and improved health across all species. This moves agricultural and biomedical science forward for the good of everyone."

Frank Blecha | EurekAlert!
Further information:
http://www.k-state.edu

More articles from Life Sciences:

nachricht What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Gravitationswellen als Sensor für Dunkle Materie

Die mit der Entdeckung von Gravitationswellen entstandene neue Disziplin der Gravitationswellen-Astronomie bekommt eine weitere Aufgabe: die Suche nach Dunkler Materie. Diese könnte aus einem Bose-Einstein-Kondensat sehr leichter Teilchen bestehen. Wie Rechnungen zeigen, würden Gravitationswellen gebremst, wenn sie durch derartige Dunkle Materie laufen. Dies führt zu einer Verspätung von Gravitationswellen relativ zu Licht, die bereits mit den heutigen Detektoren messbar sein sollte.

Im Universum muss es gut fünfmal mehr unsichtbare als sichtbare Materie geben. Woraus diese Dunkle Materie besteht, ist immer noch unbekannt. Die...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Wie sich Zellen gegen Salmonellen verteidigen

Bioinformatiker der Goethe-Universität haben das erste mathematische Modell für einen zentralen Verteidigungsmechanismus der Zelle gegen das Bakterium Salmonella entwickelt. Sie können ihren experimentell arbeitenden Kollegen damit wertvolle Anregungen zur Aufklärung der beteiligten Signalwege geben.

Jedes Jahr sind Salmonellen weltweit für Millionen von Infektionen und tausende Todesfälle verantwortlich. Die Körperzellen können sich aber gegen die...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Greifswalder Forscher dringen mit superauflösendem Mikroskop in zellulären Mikrokosmos ein

Das Institut für Anatomie und Zellbiologie weiht am Montag, 05.12.2016, mit einem wissenschaftlichen Symposium das erste Superresolution-Mikroskop in Greifswald ein. Das Forschungsmikroskop wurde von der Deutschen Forschungsgemeinschaft (DFG) und dem Land Mecklenburg-Vorpommern finanziert. Nun können die Greifswalder Wissenschaftler Strukturen bis zu einer Größe von einigen Millionstel Millimetern mittels Laserlicht sichtbar machen.

Weit über hundert Jahre lang galt die von Ernst Abbe 1873 publizierte Theorie zur Auflösungsgrenze von Lichtmikroskopen als ein in Stein gemeißeltes Gesetz....

Alle Focus-News des Innovations-reports >>>

Anzeige

Anzeige

IHR
JOB & KARRIERE
SERVICE
im innovations-report
in Kooperation mit academics
Veranstaltungen

Wie aus reinen Daten ein verständliches Bild entsteht

05.12.2016 | Veranstaltungen

Von „Coopetition“ bis „Digitale Union“ – Die Fertigungsindustrien im digitalen Wandel

02.12.2016 | Veranstaltungen

Experten diskutieren Perspektiven schrumpfender Regionen

01.12.2016 | Veranstaltungen

 
VideoLinks
B2B-VideoLinks
Weitere VideoLinks >>>
Aktuelle Beiträge

Bund fördert Entwicklung sicherer Schnellladetechnik für Hochleistungsbatterien mit 2,5 Millionen

06.12.2016 | Förderungen Preise

Innovationen für eine nachhaltige Forstwirtschaft

06.12.2016 | Agrar- Forstwissenschaften

Diabetesforschung: Neuer Mechanismus zur Regulation des Insulin-Stoffwechsels gefunden

06.12.2016 | Biowissenschaften Chemie